Peds1 plasmanylethanolamine desaturase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Peds1provided by MGI
Official Full Name: plasmanylethanolamine desaturase 1provided by MGI
Primary source: MGI:MGI:2142624
See related: Ensembl:ENSMUSG00000090213 AllianceGenome:MGI:2142624
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kua; Tmem189
Summary: Enables plasmanylethanolamine desaturase activity. Involved in ether lipid biosynthetic process. Located in endoplasmic reticulum membrane. Orthologous to several human genes including PEDS1-UBE2V1 (PEDS1-UBE2V1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in stomach adult (RPKM 220.7), kidney adult (RPKM 147.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 87.5 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (167485145..167503464, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (167643225..167661544, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Essential role of a conserved aspartate for the enzymatic activity of plasmanylethanolamine desaturase.
Title: Essential role of a conserved aspartate for the enzymatic activity of plasmanylethanolamine desaturase.
hese results assign the TMEM189 gene to plasmanylethanolamine desaturase and suggest that the previously characterized phenotype of Tmem189-deficient mice may be caused by a lack of plasmalogens.
Title: The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

General gene information

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Markers

RH136103 (e-PCR)
- UniSTS:210098

AI840826 (e-PCR)
- UniSTS:165579

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables plasmanylethanolamine desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables plasmanylethanolamine desaturase activity	IDA Inferred from Direct Assay more info	PubMed
enables plasmanylethanolamine desaturase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ether lipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ether lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plasmanylethanolamine desaturase 1

Names: plasmanylethanolamine desaturase; transmembrane protein 189

NP_663513.1

EC 1.14.19.77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.