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    Zfp119a zinc finger protein 119a [ Mus musculus (house mouse) ]

    Gene ID: 104349, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zfp119aprovided by MGI
    Official Full Name
    zinc finger protein 119aprovided by MGI
    Primary source
    MGI:MGI:1345189
    See related
    Ensembl:ENSMUSG00000057835 AllianceGenome:MGI:1345189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mzf13; Zfp119
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in alimentary system; bone; brain; and genitourinary system. Orthologous to human ZNF101 (zinc finger protein 101) and ZNF699 (zinc finger protein 699). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 1.2), bladder adult (RPKM 1.2) and 28 other tissues See more
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    Genomic context

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    Location:
    17 D; 17 29.04 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56171892..56185953, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55864886..55879457, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E4 Neighboring gene high mobility group box 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42870 Neighboring gene STARR-seq mESC enhancer starr_42871 Neighboring gene vomeronasal 2, receptor 121 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42872 Neighboring gene STARR-positive B cell enhancer ABC_E2495 Neighboring gene zinc finger protein 959 Neighboring gene predicted gene, 41603 Neighboring gene ribosomal protein L21, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes. Mark C, et al. DNA Cell Biol, 1999 May. PMID 10360839
    2. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. Khetchoumian K, et al. J Biol Chem, 2004 Nov 12. PMID 15322135
    3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 119a
    Names
    KRAB zinc finger protein
    zinc finger protein 119

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410266.1 → NP_001397195.1  zinc finger protein 119a isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT573084

    2. NM_001410267.1 → NP_001397196.1  zinc finger protein 119a isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT573084

    3. NM_001410268.1 → NP_001397197.1  zinc finger protein 119a isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT573084

    4. NM_001410269.1 → NP_001397198.1  zinc finger protein 119a isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT573084

    5. NM_001410270.1 → NP_001397199.1  zinc finger protein 119a isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT573084

    6. NM_001410271.1 → NP_001397200.1  zinc finger protein 119a isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT573084

    7. NM_001410272.1 → NP_001397201.1  zinc finger protein 119a isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT573084

    8. NM_144546.6 → NP_653129.1  zinc finger protein 119a isoform 1

      See identical proteins and their annotated locations for NP_653129.1

      Status: VALIDATED

      Source sequence(s)
      BC118950, CT573084
      Consensus CDS
      CCDS37656.1
      UniProtKB/TrEMBL
      Q9JIC0
      Conserved Domains (5) summary
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      COG5048
      Location:254 → 448
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 41
      KRAB; KRAB box
      pfam13465
      Location:331 → 356
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56171892..56185953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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