Irx2 Iroquois homeobox 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irx2provided by MGI
Official Full Name: Iroquois homeobox 2provided by MGI
Primary source: MGI:MGI:1197526
See related: Ensembl:ENSMUSG00000001504 AllianceGenome:MGI:1197526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within proximal/distal pattern formation involved in metanephric nephron development and specification of loop of Henle identity. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; autopod; central nervous system; genitourinary system; and respiratory system. Orthologous to human IRX2 (iroquois homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 35.9), mammary gland adult (RPKM 23.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 39.23 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (72771463..72782315)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (72624430..72634196)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice.
Title: IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice.
IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli.
Title: IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli.
Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.
Title: Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.
generation and phenotypic analysis of an Irx2-deficient mouse strain. Irx2-deficient mice are viable, are fertile, and appear to be normal.
Title: The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.
This homeobox protein is expressed during digit development.
Title: Expression pattern of Irx1 and Irx2 during mouse digit development.
This homeobox protein is expressed during early lung development.
Title: Irx1 and Irx2 expression in early lung development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Irx2 (e-PCR), detects polymorphism
- UniSTS:465481

Irx2 (e-PCR), detects polymorphism
- UniSTS:498331

PMC262378P1 (e-PCR)
- UniSTS:272298

PMC310936P2 (e-PCR)
- UniSTS:272819

Irx2 (e-PCR), detects polymorphism
- UniSTS:525499

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in metanephros development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proximal/distal pattern formation involved in metanephric nephron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in specification of loop of Henle identity	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: iroquois-class homeodomain protein IRX-2

Names: Iroquois related homeobox 2; homeodomain protein IRXA2; iroquois homeobox protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010574.4 → NP_034704.1 iroquois-class homeodomain protein IRX-2

See identical proteins and their annotated locations for NP_034704.1

Status: VALIDATED

Source sequence(s)

AK018266, AK148520, CT030229

Consensus CDS

CCDS26628.1

UniProtKB/Swiss-Prot

O55121, P81066, Q3UFG3, Q9ERN1, Q9JLL4

Related

ENSMUSP00000073976.5, ENSMUST00000074372.6

Conserved Domains (3) summary

smart00548
Location:325 → 342

IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function

COG5576
Location:115 → 217

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam05920
Location:133 → 172

Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

72771463..72782315

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247164.2 → XP_030103024.1 iroquois-class homeodomain protein IRX-2 isoform X1

Conserved Domains (3) summary

smart00548
Location:231 → 248

IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function

COG5576
Location:21 → 123

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam05920
Location:39 → 78

Homeobox_KN; Homeobox KN domain