Arhgap20 Rho GTPase activating protein 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap20provided by MGI
Official Full Name: Rho GTPase activating protein 20provided by MGI
Primary source: MGI:MGI:2445175
See related: Ensembl:ENSMUSG00000053199 AllianceGenome:MGI:2445175
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RARhoGAP; mKIAA1391; 6530403F17Rik; A530023E23Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in embryo mesenchyme and ovary. Orthologous to human ARHGAP20 (Rho GTPase activating protein 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 5.6), cortex adult (RPKM 5.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 28.62 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (51676651..51765158)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (51765351..51853059)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results are consistent with a cAMP/Epac2/Rap1-mediated signaling that could exert its action, among others, through RA-RhoGAP to promote the progression of spermatogenesis.
Title: cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector.
human KIAA1391 gene and mouse Kiaa1391 gene encode RhoGAP proteins with RA domain and two ANXL repeats
Title: Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

D49544 (e-PCR)
- UniSTS:181009

UniSTS:236125 (e-PCR)
- UniSTS:236125

NoName (e-PCR)
- UniSTS:236126

C87882 (e-PCR)
- UniSTS:179896

Arhgap20 (e-PCR), detects polymorphism
- UniSTS:526813

RH138047 (e-PCR)
- UniSTS:220134

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho GTPase-activating protein 20

Names: RA and RhoGAP domain-containing protein; rho-type GTPase-activating protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175535.4 → NP_780744.2 rho GTPase-activating protein 20

See identical proteins and their annotated locations for NP_780744.2

Status: VALIDATED

Source sequence(s)

AC140363, AC162806

Consensus CDS

CCDS23177.1

UniProtKB/Swiss-Prot

Q6IFT4, Q6ZPS4, Q8BLZ7, Q8BXI4

UniProtKB/TrEMBL

D3YUH8

Related

ENSMUSP00000065633.6, ENSMUST00000065496.12

Conserved Domains (3) summary

cd04402
Location:362 → 555

RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...

cd13319
Location:84 → 180

PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain

pfam00788
Location:198 → 274

RA; Ras association (RalGDS/AF-6) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

51676651..51765158

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155004.1 → XP_036010897.1 rho GTPase-activating protein 20 isoform X1

UniProtKB/TrEMBL

D3YUH8

Conserved Domains (3) summary

cd04402
Location:283 → 476

RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...

cd13319
Location:5 → 101

PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain

cd17115
Location:115 → 232

RA_RHG20; Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar proteins