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    Canx calnexin [ Mus musculus (house mouse) ]

    Gene ID: 12330, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Canxprovided by MGI
    Official Full Name
    calnexinprovided by MGI
    Primary source
    MGI:MGI:88261
    See related
    Ensembl:ENSMUSG00000020368 AllianceGenome:MGI:88261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cnx; D11Ertd153e; 1110069N15Rik
    Summary
    Predicted to enable apolipoprotein binding activity; calcium ion binding activity; and ionotropic glutamate receptor binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Located in endoplasmic reticulum quality control compartment and membrane. Is integral component of membrane. Is expressed in brain; genitourinary system; liver; and musculature. Orthologous to human CANX (calnexin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 118.8), CNS E11.5 (RPKM 79.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Canx in Genome Data Viewer
    Location:
    11 B1.3; 11 30.46 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50184784..50216500, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50293957..50325673, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene leukotriene C4 synthase Neighboring gene STARR-seq mESC enhancer starr_29394 Neighboring gene mastermind like transcriptional coactivator 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:50105936-50106045 Neighboring gene STARR-seq mESC enhancer starr_29397 Neighboring gene STARR-seq mESC enhancer starr_29398 Neighboring gene STARR-positive B cell enhancer ABC_E1417 Neighboring gene predicted gene, 46280 Neighboring gene predicted gene, 31865

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ER chaperone calnexin controls mitochondrial positioning and respiration. Gutiérrez T, et al. Sci Signal, 2020 Jun 30. PMID 32606038
    2. Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis. Bousette N, et al. J Cell Physiol, 2014 Mar. PMID 24037923
    3. Calnexin deficiency leads to dysmyelination. Kraus A, et al. J Biol Chem, 2010 Jun 11. PMID 20400506, Free PMC Article
    4. Substrate-specific requirements for UGT1-dependent release from calnexin. Soldà T, et al. Mol Cell, 2007 Jul 20. PMID 17643373
    5. Cleavage of calnexin caused by apoptotic stimuli: implication for the regulation of apoptosis. Takizawa T, et al. J Biochem, 2004 Sep. PMID 15598898

    See all (161) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ER chaperone calnexin controls mitochondrial positioning and respiration.
      Title: The ER chaperone calnexin controls mitochondrial positioning and respiration.
    2. The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis.
      Title: The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis.
    3. EBV-induced gene 3 augments IL-23Ralpha protein expression through a chaperone calnexin.
      Title: EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin.
    4. Study discovered that calnexin is highly abundant in human brain endothelial cells of multiple sclerosis (MS) patients. Conversely, mice lacking calnexin exhibited resistance to experimental autoimmune encephalomyelitis induction, no evidence of immune cell infiltration into the CNS. These findings identify a link between calnexin expression in CNS endothelial cells and neuroinflammation.
      Title: Calnexin is necessary for T cell transmigration into the central nervous system.
    5. CNX has a specific role in cardiomyocyte viability and Ca(2+) cycling through its effects on endoplasmic reticulum stress, apoptosis and Ca(2+) channel expression.
      Title: Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis.
    6. Calnexin discriminates between different conformational states of GlyT2 displaying a lectin-independent chaperone activity.
      Title: Calnexin-assisted biogenesis of the neuronal glycine transporter 2 (GlyT2).
    7. calnexin and ERp57, but not calreticulin, play an important role in the biology of peripheral myelin proteins PMP22 and P0, and, consequently, these chaperones may contribute to the pathogenesis of peripheral neuropathies
      Title: Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22.
    8. Enhanced clathrin-dependent endocytosis in the absence of calnexin may contribute to the neurological phenotype of calnexin-deficient mice
      Title: Enhanced clathrin-dependent endocytosis in the absence of calnexin.
    9. Data show that the E351 mutation led to slightly enhanced ERp57 binding to calnexin, whereas W428 greatly enhanced binding of ERp57 to calnexin.
      Title: Mutational analysis of calnexin.
    10. Suggest that Adam7 functions in fertilization through the formation of a complex with heat shock protein 5, calnexin and Itm2b during capacitation in sperm.
      Title: Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endoplasmic reticulum quality control compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calnexin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110499.1 → NP_001103969.1  calnexin precursor

      See identical proteins and their annotated locations for NP_001103969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK004422, AK017254, AK084175, AK166649, BB857984, BX632165, BY309447
      Consensus CDS
      CCDS24633.1
      UniProtKB/Swiss-Prot
      P35564
      UniProtKB/TrEMBL
      Q3TXE5, Q5SUC3
      Related
      ENSMUSP00000137440.2, ENSMUST00000179865.8
      Conserved Domains (1) summary
      pfam00262
      Location:72 → 441
      Calreticulin; Calreticulin family

    2. NM_001110500.1 → NP_001103970.1  calnexin precursor

      See identical proteins and their annotated locations for NP_001103970.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK004422, AK017254, AK028279, AK165508, BX632165, BY309447
      Consensus CDS
      CCDS24633.1
      UniProtKB/Swiss-Prot
      P35564
      UniProtKB/TrEMBL
      Q3TXE5, Q5SUC3
      Conserved Domains (1) summary
      pfam00262
      Location:72 → 441
      Calreticulin; Calreticulin family

    3. NM_007597.3 → NP_031623.1  calnexin precursor

      See identical proteins and their annotated locations for NP_031623.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK004422, AK017254, AK084175, AK166649, BX632165, BY309447
      Consensus CDS
      CCDS24633.1
      UniProtKB/Swiss-Prot
      P35564
      UniProtKB/TrEMBL
      Q3TXE5, Q5SUC3
      Related
      ENSMUSP00000020637.9, ENSMUST00000020637.9
      Conserved Domains (1) summary
      pfam00262
      Location:72 → 441
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50184784..50216500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35564.1 GenPept UniProtKB/Swiss-Prot:P35564

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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