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    Syce2 synaptonemal complex central element protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 71846, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Syce2provided by MGI
    Official Full Name
    synaptonemal complex central element protein 2provided by MGI
    Primary source
    MGI:MGI:1919096
    See related
    Ensembl:ENSMUSG00000003824 AllianceGenome:MGI:1919096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cesc1; 1700013H19Rik
    Summary
    Predicted to act upstream of or within synaptonemal complex assembly. Located in central element. Is expressed in primary spermatocyte and spermatocyte. Orthologous to human SYCE2 (synaptonemal complex central element protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 31.9), liver E14 (RPKM 10.9) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C3; 8 41.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85598740..85614075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84872111..84887446)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene predicted gene 5911 Neighboring gene phenylalanyl-tRNA synthetase, alpha subunit Neighboring gene STARR-positive B cell enhancer ABC_E11391 Neighboring gene microRNA 7069 Neighboring gene glutaryl-Coenzyme A dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E1763 Neighboring gene predicted gene, 39213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87427053-87427162 Neighboring gene Kruppel-like transcription factor 1 (erythroid)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination. Bolcun-Filas E, et al. J Cell Biol, 2007 Mar 12. PMID 17339376, Free PMC Article
    2. Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution. Schücker K, et al. Proc Natl Acad Sci U S A, 2015 Feb 17. PMID 25646409, Free PMC Article
    3. Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components. Fraune J, et al. Genetics, 2013 Nov. PMID 24026100, Free PMC Article
    4. The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly. Pyatnitskaya A, et al. Genes Dev, 2022 Jan 1. PMID 34969823, Free PMC Article
    5. SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60. Shi YQ, et al. Gene, 2013 Sep 15. PMID 23810942

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLX2 interacts with synaptonemal complex central element protein 2 (SYCE2), an important component of synaptonemal complex.
      Title: SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.
    2. Synaptonemal complex assembly is dependent on SYCE2.
      Title: SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination.
    3. The localisation of Syce1 and Cesc1 (Syce2) to the central element depends on recruitment by Sycp1.
      Title: Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within synaptonemal complex assembly IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in central element IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in central element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptonemal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptonemal complex central element protein 2
    Names
    central element synaptonemal complex 1
    central element synaptonemal complex protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168244.1 → NP_001161716.1  synaptonemal complex central element protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001161716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC161765, AK082833, AK167332
      UniProtKB/Swiss-Prot
      Q505B8

    2. NM_001168246.1 → NP_001161718.1  synaptonemal complex central element protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC161765
      Consensus CDS
      CCDS52620.1
      UniProtKB/TrEMBL
      A2RTK0, E9PYH4
      Related
      ENSMUSP00000131438.2, ENSMUST00000170296.2

    3. NM_027954.3 → NP_082230.2  synaptonemal complex central element protein 2 isoform 2

      See identical proteins and their annotated locations for NP_082230.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1
      Source sequence(s)
      AC161765, AK005954, AK082833, BY246600
      Consensus CDS
      CCDS22481.1
      UniProtKB/Swiss-Prot
      Q3TJR1, Q505B8, Q9DAC4
      UniProtKB/TrEMBL
      A2RTK0
      Related
      ENSMUSP00000122159.2, ENSMUST00000136026.8

    RNA

    1. NR_031759.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC161765, AK082833, BY083329
      Related
      ENSMUST00000003922.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85598740..85614075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q505B8.1 GenPept UniProtKB/Swiss-Prot:Q505B8

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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