Impa1 inositol (myo)-1(or 4)-monophosphatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Impa1provided by MGI
Official Full Name: inositol (myo)-1(or 4)-monophosphatase 1provided by MGI
Primary source: MGI:MGI:1933158
See related: Ensembl:ENSMUSG00000027531 AllianceGenome:MGI:1933158
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610002K09Rik; 2900059K10Rik
Summary: Enables magnesium ion binding activity. Predicted to be involved in phosphatidylinositol biosynthetic process; polyol metabolic process; and signal transduction. Predicted to be located in axon; cytoplasm; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human IMPA1 (inositol monophosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 9.6), cerebellum adult (RPKM 9.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A1; 3 2.61 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (10377016..10396499, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (10311956..10331439, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol, consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior
Title: IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.
IMPase has a role in intracellular myo-inositol synthesis in craniofacial development and the maintenance of proper brain function
Title: Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.
Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A
Title: Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.
local synthesis of IMPA1 is required for neurotrophin-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases
Title: An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons.
IMPA1-/- mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium
Title: IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity.
Results suggest that calbindin D28k acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound myo-inositol monophosphatase in central neurons.
Title: Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons.
IMPA2 has a separate function in vivo from that of IMPA1
Title: Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1.
IMPA1 was expressed in round spermatids
Title: Characterization of the expression and regulation of genes necessary for myo-inositol biosynthesis and transport in the seminiferous epithelium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI325909 (e-PCR)
- UniSTS:178805

Impa1 (e-PCR), detects polymorphism
- UniSTS:528629

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables inositol monophosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol monophosphate 1-phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables inositol monophosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 4-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lithium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inositol metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in phosphate-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inositol monophosphatase 1

Names: D-galactose 1-phosphate phosphatase; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1; myo-inositol monophosphatase 1

NP_001297362.1

EC 3.1.3.25

EC 3.1.3.94

NP_061352.2

EC 3.1.3.25

EC 3.1.3.94

XP_006530140.1

EC 3.1.3.25

EC 3.1.3.94

XP_006530141.1

EC 3.1.3.25

EC 3.1.3.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310433.2 → NP_001297362.1 inositol monophosphatase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC123726

Consensus CDS

CCDS79884.1

UniProtKB/TrEMBL

A0A0A6YW07

Related

ENSMUSP00000141345.2, ENSMUST00000191670.6

Conserved Domains (1) summary

cd01639
Location:8 → 164

IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...
NM_001428861.1 → NP_001415790.1 inositol monophosphatase 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC123726
NM_001428862.1 → NP_001415791.1 inositol monophosphatase 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC123726
NM_001428863.1 → NP_001415792.1 inositol monophosphatase 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC123726
NM_018864.7 → NP_061352.2 inositol monophosphatase 1 isoform 1

See identical proteins and their annotated locations for NP_061352.2

Status: VALIDATED

Source sequence(s)

AC123726

Consensus CDS

CCDS17240.1

UniProtKB/TrEMBL

Q3TME6, Q3U5R8, Q924B0, Q9D066

Related

ENSMUSP00000068174.9, ENSMUST00000065938.15

Conserved Domains (1) summary

cd01639
Location:8 → 254

IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

10377016..10396499 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530077.4 → XP_006530140.1 inositol monophosphatase 1 isoform X1

UniProtKB/TrEMBL

Q3TME6, Q3U5R8, Q9D066

Conserved Domains (1) summary

cd01639
Location:61 → 307

IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...
XM_006530078.5 → XP_006530141.1 inositol monophosphatase 1 isoform X2

Conserved Domains (1) summary

cd01639
Location:61 → 217

IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...