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    Slc9b1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 74446, updated on 2-May-2024

    Summary

    Official Symbol
    Slc9b1provided by MGI
    Official Full Name
    solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1provided by MGI
    Primary source
    MGI:MGI:1921696
    See related
    Ensembl:ENSMUSG00000050150 AllianceGenome:MGI:1921696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nhedc1; mtsNHE; 1700094G20Rik; 4933424B12Rik; 4933425K02Rik
    Summary
    Predicted to enable solute:proton antiporter activity. Involved in flagellated sperm motility and regulation of intracellular pH. Located in sperm principal piece. Orthologous to several human genes including SLC9B1 (solute carrier family 9 member B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 25.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    3 G3; 3 62.55 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135053754..135103588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135347993..135397827)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46826 Neighboring gene 3-hydroxybutyrate dehydrogenase, type 2 Neighboring gene STARR-seq mESC enhancer starr_09056 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Neighboring gene STARR-seq mESC enhancer starr_09057 Neighboring gene STARR-seq mESC enhancer starr_09058 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135065430-135065659 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene RIKEN cDNA 4930539J05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135101299-135101408 Neighboring gene ubiquitin-conjugating enzyme E2D 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inorganic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of intracellular pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium/hydrogen exchanger 9B1
    Names
    NHE domain-containing protein 1
    Na(+)/H(+) exchanger-like domain-containing protein 1
    Na+/H+ exchanger domain containing 1
    sodium/hydrogen exchanger-like domain-containing protein 1
    solute carrier family 9 subfamily B member 1
    testis specific sodium-hydrogen exchanger

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358057.1NP_001344986.1  sodium/hydrogen exchanger 9B1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104874, AK016917
      Related
      ENSMUST00000160460.8
      Conserved Domains (1) summary
      cl01133
      Location:207355
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    2. NM_028946.4NP_083222.2  sodium/hydrogen exchanger 9B1 isoform 1

      See identical proteins and their annotated locations for NP_083222.2

      Status: VALIDATED

      Source sequence(s)
      AC156618, AK029525, AV262918, BX525256
      Consensus CDS
      CCDS17855.2
      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Related
      ENSMUSP00000077644.6, ENSMUST00000078568.12
      Conserved Domains (1) summary
      cl01133
      Location:207551
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      135053754..135103588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240253.3XP_011238555.1  sodium/hydrogen exchanger 9B1 isoform X3

      Conserved Domains (1) summary
      cl01133
      Location:207269
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    2. XM_017319776.1XP_017175265.1  sodium/hydrogen exchanger 9B1 isoform X1

      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Conserved Domains (1) summary
      cl01133
      Location:207551
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    3. XM_017319775.1XP_017175264.1  sodium/hydrogen exchanger 9B1 isoform X1

      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Conserved Domains (1) summary
      cl01133
      Location:207551
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    4. XM_011240251.2XP_011238553.1  sodium/hydrogen exchanger 9B1 isoform X1

      See identical proteins and their annotated locations for XP_011238553.1

      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Conserved Domains (1) summary
      cl01133
      Location:207551
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    5. XM_006502201.3XP_006502264.1  sodium/hydrogen exchanger 9B1 isoform X1

      See identical proteins and their annotated locations for XP_006502264.1

      UniProtKB/Swiss-Prot
      B5AFL0, Q8C0X2, Q8C1I8, Q8R3N0, Q9CPR9, Q9D400
      UniProtKB/TrEMBL
      G5E8I2
      Conserved Domains (1) summary
      cl01133
      Location:207551
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    6. XM_011240252.2XP_011238554.1  sodium/hydrogen exchanger 9B1 isoform X2

      Conserved Domains (1) summary
      cl01133
      Location:207400
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RNA

    1. XR_867240.1 RNA Sequence