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    C1qtnf6 C1q and tumor necrosis factor related protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 72709, updated on 21-Apr-2024

    Summary

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    Official Symbol
    C1qtnf6provided by MGI
    Official Full Name
    C1q and tumor necrosis factor related protein 6provided by MGI
    Primary source
    MGI:MGI:1919959
    See related
    Ensembl:ENSMUSG00000022440 AllianceGenome:MGI:1919959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adiq; CTRP6; 2810036M19Rik
    Summary
    Enables identical protein binding activity. Located in extracellular space. Part of protein-containing complex. Orthologous to human C1QTNF6 (C1q and TNF related 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 62.8), limb E14.5 (RPKM 28.7) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E1; 15 37.55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78407546..78416370, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78523346..78532170, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 6 Neighboring gene STARR-positive B cell enhancer ABC_E8598 Neighboring gene STARR-seq mESC enhancer starr_39146 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78306098-78306207 Neighboring gene interleukin 2 receptor, beta chain Neighboring gene STARR-positive B cell enhancer ABC_E4139 Neighboring gene STARR-seq mESC enhancer starr_39149 Neighboring gene somatostatin receptor 3 Neighboring gene L antigen family, member 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CTRP6 suppresses neutrophil extracellular traps formation to ameliorate sepsis-induced lung injury through inactivation of ERK pathway. Li J, et al. Allergol Immunopathol (Madr), 2022. PMID 36335445
    2. CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt). Liu Z, et al. Bioengineered, 2021 Dec. PMID 34516328, Free PMC Article
    3. C1qTNF-related protein-6 protects against doxorubicin-induced cardiac injury. Zheng WF, et al. J Cell Biochem, 2019 Jun. PMID 30719766
    4. Lentivirus-mediated CTRP6 silencing ameliorates diet-induced obesity in mice. Wu W, et al. Exp Cell Res, 2018 Jun 1. PMID 29366805
    5. Knockdown of CTRP6 inhibits adipogenesis via lipogenic marker genes and Erk1/2 signalling pathway. Wu WJ, et al. Cell Biol Int, 2015 May. PMID 25639984

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTRP6 promotes the macrophage inflammatory response, and its deficiency attenuates LPS-induced inflammation.
      Title: CTRP6 promotes the macrophage inflammatory response, and its deficiency attenuates LPS-induced inflammation.
    2. CTRP6 suppresses neutrophil extracellular traps formation to ameliorate sepsis-induced lung injury through inactivation of ERK pathway.
      Title: CTRP6 suppresses neutrophil extracellular traps formation to ameliorate sepsis-induced lung injury through inactivation of ERK pathway.
    3. CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt).
      Title: CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt).
    4. CTRP6 rapidly responds to acute nutritional changes, regulating adipose tissue expansion and inflammation in mice.
      Title: CTRP6 rapidly responds to acute nutritional changes, regulating adipose tissue expansion and inflammation in mice.
    5. Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation.
      Title: Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation.
    6. CTRP6 protected the heart from doxorubicin cardiotoxicity and improved cardiac function via activation of the AKT signaling pathway.
      Title: C1qTNF-related protein-6 protects against doxorubicin-induced cardiac injury.
    7. CTRP6 knockdown protects against diet-induced obesity and promotes brown adipogenesis in mice.
      Title: Lentivirus-mediated CTRP6 silencing ameliorates diet-induced obesity in mice.
    8. The results establish CTRP6 as a novel metabolic/immune regulator linking obesity to adipose tissue inflammation and insulin resistance.
      Title: C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance.
    9. CTRP6 knockdown down-regulated the levels of lipogenic genes and phosphorylated Erk1/2 (p-Erk1/2) in the early lipogenic stage, whereas up-regulated p-Erk1/2 in the terminal differentiation in skeletal myoblasts.
      Title: Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPARγ signaling pathway.
    10. CTRP6 specifically suppresses the alternative pathway of the complement system. C1qtnf6(-/-) mice are highly susceptible to induced arthritis, Arthus reaction, and experimental autoimmune encephalomyelitis.
      Title: CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C1q tumor necrosis factor-related protein 6
    Names
    adiponectin q

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204152.1 → NP_001191081.1  complement C1q tumor necrosis factor-related protein 6 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001191081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI853798, AK012868, AL590144
      Consensus CDS
      CCDS88801.1
      UniProtKB/TrEMBL
      A0A2R8W6P9
      Related
      ENSMUSP00000155221.2, ENSMUST00000229185.2

    2. NM_001204153.1 → NP_001191082.1  complement C1q tumor necrosis factor-related protein 6 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001191082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL590144
      Related
      ENSMUST00000147093.2

    3. NM_028331.5 → NP_082607.3  complement C1q tumor necrosis factor-related protein 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_082607.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI853798, AK012868, AL590144, DQ002399
      Consensus CDS
      CCDS37134.1
      UniProtKB/Swiss-Prot
      Q6IR41, Q8BKR0
      UniProtKB/TrEMBL
      A0A3B0IP29
      Related
      ENSMUSP00000023075.9, ENSMUST00000023075.9
      Conserved Domains (2) summary
      pfam01391
      Location:83 → 122
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:131 → 259
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78407546..78416370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521455.4 → XP_006521518.1  complement C1q tumor necrosis factor-related protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006521518.1

      Conserved Domains (2) summary
      pfam01391
      Location:79 → 118
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:127 → 255
      C1q; C1q domain

    2. XM_006521452.5 → XP_006521515.1  complement C1q tumor necrosis factor-related protein 6 isoform X2

      Conserved Domains (2) summary
      pfam01391
      Location:111 → 150
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:159 → 287
      C1q; C1q domain

    3. XM_036159608.1 → XP_036015501.1  complement C1q tumor necrosis factor-related protein 6 isoform X1

      Conserved Domains (2) summary
      pfam00386
      Location:175 → 303
      C1q; C1q domain
      pfam01391
      Location:127 → 166
      Collagen; Collagen triple helix repeat (20 copies)

    4. XM_006521453.4 → XP_006521516.1  complement C1q tumor necrosis factor-related protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006521516.1

      Conserved Domains (2) summary
      pfam01391
      Location:79 → 118
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:127 → 255
      C1q; C1q domain

    5. XM_036159609.1 → XP_036015502.1  complement C1q tumor necrosis factor-related protein 6 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IR41.1 GenPept UniProtKB/Swiss-Prot:Q6IR41

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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