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    Zfp266 zinc finger protein 266 [ Mus musculus (house mouse) ]

    Gene ID: 77519, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zfp266provided by MGI
    Official Full Name
    zinc finger protein 266provided by MGI
    Primary source
    MGI:MGI:1924769
    See related
    Ensembl:ENSMUSG00000060510 AllianceGenome:MGI:1924769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5330440G10Rik; 5730601F06Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in central nervous system; liver; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human ZNF266 (zinc finger protein 266); ZNF561 (zinc finger protein 561); and ZNF562 (zinc finger protein 562). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 3.9), CNS E14 (RPKM 2.8) and 22 other tissues See more
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    Genomic context

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    Location:
    9 A3; 9 7.56 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20406364..20432715, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20495068..20521419, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 26 Neighboring gene STARR-positive B cell enhancer ABC_E9753 Neighboring gene zinc finger protein 426 Neighboring gene predicted gene, 23316 Neighboring gene predicted gene, 46142 Neighboring gene STARR-positive B cell enhancer ABC_E6716 Neighboring gene predicted gene, 51704 Neighboring gene zinc finger protein 846

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors. Kaemena DF, et al. Nat Commun, 2023 Jan 30. PMID 36717582, Free PMC Article
    2. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.
      Title: B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 561

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082485.1 → NP_001075954.1  zinc finger protein 561

      See identical proteins and their annotated locations for NP_001075954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC171206, BC089552, BM941296, CJ053742
      Consensus CDS
      CCDS52732.1
      UniProtKB/TrEMBL
      E9Q2S7
      Related
      ENSMUSP00000134217.2, ENSMUST00000174462.8
      Conserved Domains (4) summary
      smart00349
      Location:41 → 97
      KRAB; krueppel associated box
      COG5048
      Location:397 → 588
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:429 → 449
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:357 → 382
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001135019.1 → NP_001128491.1  zinc finger protein 561

      See identical proteins and their annotated locations for NP_001128491.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC171206, BC048701, BM941296, CJ053742
      Consensus CDS
      CCDS52732.1
      UniProtKB/TrEMBL
      E9Q2S7
      Related
      ENSMUSP00000066012.8, ENSMUST00000068296.8
      Conserved Domains (4) summary
      smart00349
      Location:41 → 97
      KRAB; krueppel associated box
      COG5048
      Location:397 → 588
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:429 → 449
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:357 → 382
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20406364..20432715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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