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    Nsmce1 NSE1 homolog, SMC5-SMC6 complex component [ Mus musculus (house mouse) ]

    Gene ID: 67711, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nsmce1provided by MGI
    Official Full Name
    NSE1 homolog, SMC5-SMC6 complex componentprovided by MGI
    Primary source
    MGI:MGI:1914961
    See related
    Ensembl:ENSMUSG00000030750 AllianceGenome:MGI:1914961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510027N19Rik
    Summary
    Predicted to enable protein dimerization activity and ubiquitin protein ligase activity. Predicted to be involved in double-strand break repair via homologous recombination; positive regulation of response to DNA damage stimulus; and postreplication repair. Predicted to act upstream of or within DNA recombination and DNA repair. Located in chromosome, centromeric region; mitotic spindle pole; and nucleus. Part of Smc5-Smc6 complex. Is expressed in pancreas epithelium. Orthologous to human NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 62.5), placenta adult (RPKM 30.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 68.87 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125066816..125090615, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (125467644..125491443, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20121 Neighboring gene predicted gene, 30717 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132587967-132588150 Neighboring gene lysine (K)-specific demethylase 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132615846-132616029 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132635019-132635206 Neighboring gene STARR-positive B cell enhancer ABC_E3749 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:132700351-132700626 Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene Neighboring gene interleukin 4 receptor, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A transcriptomic analysis of Nsmce1 overexpression in mouse hippocampal neuronal cell by RNA sequencing. Gong M, et al. Funct Integr Genomics, 2020 May. PMID 31792732
    2. Nse1 and Nse4, subunits of the Smc5-Smc6 complex, are involved in Dictyostelium development upon starvation. Taniura H, et al. Dev Growth Differ, 2015 Aug. PMID 26036668
    3. Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression. Pryzhkova MV, et al. J Cell Sci, 2016 Apr 15. PMID 26919979, Free PMC Article
    4. SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Hwang G, et al. Development, 2017 May 1. PMID 28302748, Free PMC Article
    5. Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase. Gur I, et al. PLoS One, 2014. PMID 24911587, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A transcriptomic analysis of Nsmce1 overexpression in mouse hippocampal neuronal cell by RNA sequencing.
      Title: A transcriptomic analysis of Nsmce1 overexpression in mouse hippocampal neuronal cell by RNA sequencing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    non-structural maintenance of chromosomes element 1 homolog
    Names
    non-SMC element 1 homolog
    NP_001347588.2
    NP_001363939.1
    NP_001363940.1
    NP_001363941.1
    NP_001410382.1
    NP_001410383.1
    NP_001410384.1
    NP_001410386.1
    NP_001410387.1
    NP_001410388.1
    NP_080606.3
    XP_036009279.1
    XP_036009282.1
    XP_036009283.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360659.2 → NP_001347588.2  non-structural maintenance of chromosomes element 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK011011, BC049558, W80039
      Conserved Domains (2) summary
      cd16493
      Location:177 → 221
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 162
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    2. NM_001377010.1 → NP_001363939.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125187
      UniProtKB/Swiss-Prot
      Q3TLN4, Q8K2B4, Q9CY20, Q9D720
      Conserved Domains (2) summary
      cd16493
      Location:190 → 234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    3. NM_001377011.1 → NP_001363940.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125187
      UniProtKB/Swiss-Prot
      Q3TLN4, Q8K2B4, Q9CY20, Q9D720
      Conserved Domains (2) summary
      cd16493
      Location:190 → 234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    4. NM_001377012.2 → NP_001363941.1  non-structural maintenance of chromosomes element 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125187
      Conserved Domains (2) summary
      cd16493
      Location:177 → 221
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 162
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    5. NM_001423453.1 → NP_001410382.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125187
      UniProtKB/Swiss-Prot
      Q3TLN4, Q8K2B4, Q9CY20, Q9D720

    6. NM_001423454.1 → NP_001410383.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125187
      UniProtKB/Swiss-Prot
      Q3TLN4, Q8K2B4, Q9CY20, Q9D720

    7. NM_001423455.1 → NP_001410384.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125187
      UniProtKB/Swiss-Prot
      Q3TLN4, Q8K2B4, Q9CY20, Q9D720

    8. NM_001423457.1 → NP_001410386.1  non-structural maintenance of chromosomes element 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125187

    9. NM_001423458.1 → NP_001410387.1  non-structural maintenance of chromosomes element 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125187

    10. NM_001423459.1 → NP_001410388.1  non-structural maintenance of chromosomes element 1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125187

    11. NM_026330.4 → NP_080606.3  non-structural maintenance of chromosomes element 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK011011, BC049558
      UniProtKB/Swiss-Prot
      Q3TLN4, Q8K2B4, Q9CY20, Q9D720
      Related
      ENSMUSP00000033006.8, ENSMUST00000033006.14
      Conserved Domains (2) summary
      cd16493
      Location:190 → 234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      125066816..125090615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153386.1 → XP_036009279.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q3TLN4, Q8K2B4, Q9CY20, Q9D720
      Conserved Domains (2) summary
      cd16493
      Location:190 → 234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    2. XM_036153390.1 → XP_036009283.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q3TLN4, Q8K2B4, Q9CY20, Q9D720
      Conserved Domains (2) summary
      cd16493
      Location:190 → 234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    3. XM_036153389.1 → XP_036009282.1  non-structural maintenance of chromosomes element 1 homolog isoform X3

      Conserved Domains (2) summary
      cd16493
      Location:94 → 138
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:1 → 79
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D720.1 GenPept UniProtKB/Swiss-Prot:Q9D720

    Gene LinkOut

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