Dpy19l2 dpy-19 like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpy19l2provided by MGI
Official Full Name: dpy-19 like 2provided by MGI
Primary source: MGI:MGI:2444662
See related: Ensembl:ENSMUSG00000085576 AllianceGenome:MGI:2444662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm18376; 4932443J21Rik
Summary: Predicted to enable mannosyltransferase activity. Acts upstream of or within spermatid development. Located in nuclear inner membrane. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in spermatogenic failure 9. Orthologous to several human genes including DPY19L2 (dpy-19 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 21.8) See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 10.22 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (24468343..24607752, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (24557047..24696457, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Dpy19l2 knock-out round spermatids, the detachment of the acrosome leads to Sun5 and lamin B1 relocalization, confirming that Sun5 protein is excluded from the nuclear envelope facing the acrosome.
Title: Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.
Absence of Dpy19l2 leads to the destabilization of both the nuclear dense lamina and the junction between the acroplaxome and the nuclear envelope in spermatids. Consequently, the acrosome and the manchette fail to be linked to the nucleus.
Title: Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatid development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable C-mannosyltransferase DPY19L2

Names: dpy-19-like protein 2; protein dpy-19 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166207.1 → NP_001159679.1 probable C-mannosyltransferase DPY19L2

See identical proteins and their annotated locations for NP_001159679.1

Status: VALIDATED

Source sequence(s)

AK029497, AK030128, AV254516

Consensus CDS

CCDS52743.1

UniProtKB/Swiss-Prot

P0CW70

Related

ENSMUSP00000132092.2, ENSMUST00000133010.4

Conserved Domains (1) summary

pfam10034
Location:130 → 771

Dpy19; Q-cell neuroblast polarization

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

24468343..24607752 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510428.5 → XP_006510491.1 probable C-mannosyltransferase DPY19L2 isoform X2

Conserved Domains (1) summary

pfam10034
Location:130 → 730

Dpy19; Q-cell neuroblast polarisation
XM_006510427.5 → XP_006510490.1 probable C-mannosyltransferase DPY19L2 isoform X1

Conserved Domains (1) summary

pfam10034
Location:130 → 745

Dpy19; Q-cell neuroblast polarisation
XM_011242557.3 → XP_011240859.1 probable C-mannosyltransferase DPY19L2 isoform X4

Conserved Domains (1) summary

pfam10034
Location:1 → 502

Dpy19; Q-cell neuroblast polarisation
XM_030244421.1 → XP_030100281.1 probable C-mannosyltransferase DPY19L2 isoform X5

Conserved Domains (1) summary

pfam10034
Location:4 → 411

Dpy19; Q-cell neuroblast polarisation
XM_011242556.4 → XP_011240858.1 probable C-mannosyltransferase DPY19L2 isoform X3

Conserved Domains (1) summary

pfam10034
Location:130 → 531

Dpy19; Q-cell neuroblast polarisation
XM_017313436.2 → XP_017168925.1 probable C-mannosyltransferase DPY19L2 isoform X6

Conserved Domains (1) summary

pfam10034
Location:130 → 378

Dpy19; Q-cell neuroblast polarisation

RNA

XR_870529.4 RNA Sequence
XR_001778933.3 RNA Sequence
XR_379122.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_020863.1: Suppressed sequence

Description

NG_020863.1: This RefSeq was permanently suppressed because it is now thought that this gene is not a pseudogene.