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    Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [ Mus musculus (house mouse) ]

    Gene ID: 22630, updated on 11-Apr-2024

    Summary

    Official Symbol
    Ywhaqprovided by MGI
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaprovided by MGI
    Primary source
    MGI:MGI:891963
    See related
    Ensembl:ENSMUSG00000076432 AllianceGenome:MGI:891963
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700028P07Rik
    Summary
    Enables protein domain specific binding activity. Acts upstream of or within protein targeting and small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 170.8), CNS E14 (RPKM 138.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    Location:
    12 A1.3; 12 8.31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (21440330..21467437, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (21390329..21417436, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1152 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog Neighboring gene a disintegrin and metallopeptidase domain 17 Neighboring gene predicted gene, 22766 Neighboring gene RIKEN cDNA F630048H11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr12:21423322-21423623 Neighboring gene predicted gene 4419 Neighboring gene STARR-positive B cell enhancer ABC_E5323 Neighboring gene predicted gene, 31676

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118161

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    14-3-3 protein theta
    Names
    14-3-3 protein T-cell
    14-3-3 protein tau
    14-3-3 tau
    14-3-3 theta
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011739.3NP_035869.1  14-3-3 protein theta

      See identical proteins and their annotated locations for NP_035869.1

      Status: PROVISIONAL

      Source sequence(s)
      AC140457
      Consensus CDS
      CCDS25837.1
      UniProtKB/Swiss-Prot
      P35216, P68254, Q3TW69, Q3UJN5, Q5SP76, Q5U423, Q66JR6
      UniProtKB/TrEMBL
      A3KML3
      Related
      ENSMUSP00000100067.2, ENSMUST00000103002.8
      Conserved Domains (1) summary
      cd10023
      Location:1234
      14-3-3_theta; 14-3-3 theta/tau (theta in mice, tau in human), an isoform of 14-3-3 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      21440330..21467437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)