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    Ube2h ubiquitin-conjugating enzyme E2H [ Mus musculus (house mouse) ]

    Gene ID: 22214, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ube2hprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Hprovided by MGI
    Primary source
    MGI:MGI:104632
    See related
    Ensembl:ENSMUSG00000039159 AllianceGenome:MGI:104632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gid3; Ubc8; E2-20K; 1500009C23Rik
    Summary
    Enables ubiquitin conjugating enzyme activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human UBE2H (ubiquitin conjugating enzyme E2 H). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 28.8), bladder adult (RPKM 28.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30211288..30304538, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30211289..30304539, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene expressed sequence BB283400 Neighboring gene predicted gene, 31221 Neighboring gene STARR-seq mESC enhancer starr_15462 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30250507-30250717 Neighboring gene RIKEN cDNA 1700095J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E4817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30290290-30290473 Neighboring gene STARR-seq mESC enhancer starr_15465 Neighboring gene STARR-positive B cell enhancer mm9_chr6:30307653-30307954 Neighboring gene zinc finger, C3HC type 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme. Wefes I, et al. Gene, 1995 Oct 3. PMID 7590289
    2. Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. Wefes I, et al. Proc Natl Acad Sci U S A, 1995 May 23. PMID 7761435, Free PMC Article
    3. MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. Yi JS, et al. Nat Commun, 2013. PMID 23965929, Free PMC Article
    4. Human-mouse comparative mapping of the genomic region containing CDK6: localization of an evolutionary breakpoint. Thomas JW, et al. Mamm Genome, 1999 Jul. PMID 10384057
    5. Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Kim KI, et al. Mol Cell Biol, 2004 Nov. PMID 15485925, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H.
      Title: MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 H
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme H
    E2 ubiquitin-conjugating enzyme H
    UBCH2
    ubiquitin carrier protein H
    ubiquitin-conjugating enzyme E2-20K
    ubiquitin-protein ligase H
    NP_001163047.1
    NP_001163048.1
    NP_033485.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169576.1 → NP_001163047.1  ubiquitin-conjugating enzyme E2 H isoform 2

      See identical proteins and their annotated locations for NP_001163047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC161538, AK131688, AK161414, CF539343
      Consensus CDS
      CCDS51743.1
      UniProtKB/TrEMBL
      E9Q3U1, Q3TTE3
      Related
      ENSMUSP00000092121.3, ENSMUST00000094543.3
      Conserved Domains (1) summary
      cl00154
      Location:31 → 114
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_001169577.1 → NP_001163048.1  ubiquitin-conjugating enzyme E2 H isoform 3

      See identical proteins and their annotated locations for NP_001163048.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC161538
      Conserved Domains (1) summary
      cl00154
      Location:1 → 75
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_009459.3 → NP_033485.1  ubiquitin-conjugating enzyme E2 H isoform 1

      See identical proteins and their annotated locations for NP_033485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC161538, AK131688, CF539343
      Consensus CDS
      CCDS19969.1
      UniProtKB/Swiss-Prot
      P62257
      UniProtKB/TrEMBL
      Q3TTE3, Q3V2N4
      Related
      ENSMUSP00000100058.4, ENSMUST00000102993.10
      Conserved Domains (1) summary
      pfam00179
      Location:31 → 145
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30211288..30304538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62257.1 GenPept UniProtKB/Swiss-Prot:P62257

    Gene LinkOut

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