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    Tc2n tandem C2 domains, nuclear [ Mus musculus (house mouse) ]

    Gene ID: 74413, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tc2nprovided by MGI
    Official Full Name
    tandem C2 domains, nuclearprovided by MGI
    Primary source
    MGI:MGI:1921663
    See related
    Ensembl:ENSMUSG00000021187 AllianceGenome:MGI:1921663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tac2-N; Mtac2d1; 4933406D09Rik
    Summary
    Located in nucleus. Orthologous to human TC2N (tandem C2 domains, nuclear). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 2.4), testis adult (RPKM 0.5) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 E; 12 51.26 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (101611705..101685178, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (101645446..101718919, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cation channel, sperm-associated, beta pseudogene Neighboring gene predicted gene, 22749 Neighboring gene STARR-seq mESC enhancer starr_33085 Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene STARR-seq mESC enhancer starr_33086 Neighboring gene predicted gene, 52022 Neighboring gene STARR-seq mESC enhancer starr_33088 Neighboring gene fibulin 5 Neighboring gene STARR-seq mESC enhancer starr_33091 Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene predicted gene, 20036

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. Fukuda M, et al. FEBS Lett, 2001 Aug 17. PMID 11526914
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tandem C2 domains nuclear protein
    Names
    membrane targeting (tandem) C2 domain containing 1
    membrane targeting tandem C2 domain-containing protein 1
    tandem C2 protein in nucleus

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082976.2 → NP_001076445.1  tandem C2 domains nuclear protein

      See identical proteins and their annotated locations for NP_001076445.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC125355, AK016683, AK136558, EH095356
      Consensus CDS
      CCDS36524.1
      UniProtKB/Swiss-Prot
      Q3UW74, Q91XT6, Q9D4A0
      UniProtKB/TrEMBL
      E0CXQ6
      Related
      ENSMUSP00000125288.2, ENSMUST00000162735.8
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    2. NM_028924.3 → NP_083200.1  tandem C2 domains nuclear protein

      See identical proteins and their annotated locations for NP_083200.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC125355, BC120793, BE624960, EH095356
      Consensus CDS
      CCDS36524.1
      UniProtKB/Swiss-Prot
      Q3UW74, Q91XT6, Q9D4A0
      UniProtKB/TrEMBL
      E0CXQ6
      Related
      ENSMUSP00000124287.2, ENSMUST00000160830.2
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      101611705..101685178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516303.4 → XP_006516366.1  tandem C2 domains nuclear protein isoform X1

      See identical proteins and their annotated locations for XP_006516366.1

      UniProtKB/Swiss-Prot
      Q3UW74, Q91XT6, Q9D4A0
      UniProtKB/TrEMBL
      E0CXQ6
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    2. XM_011244191.3 → XP_011242493.1  tandem C2 domains nuclear protein isoform X1

      See identical proteins and their annotated locations for XP_011242493.1

      UniProtKB/Swiss-Prot
      Q3UW74, Q91XT6, Q9D4A0
      UniProtKB/TrEMBL
      E0CXQ6
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    3. XM_017315217.3 → XP_017170706.1  tandem C2 domains nuclear protein isoform X1

      UniProtKB/Swiss-Prot
      Q3UW74, Q91XT6, Q9D4A0
      UniProtKB/TrEMBL
      E0CXQ6
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    4. XM_006516301.5 → XP_006516364.1  tandem C2 domains nuclear protein isoform X1

      See identical proteins and their annotated locations for XP_006516364.1

      UniProtKB/Swiss-Prot
      Q3UW74, Q91XT6, Q9D4A0
      UniProtKB/TrEMBL
      E0CXQ6
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    5. XM_011244192.2 → XP_011242494.1  tandem C2 domains nuclear protein isoform X1

      See identical proteins and their annotated locations for XP_011242494.1

      UniProtKB/Swiss-Prot
      Q3UW74, Q91XT6, Q9D4A0
      UniProtKB/TrEMBL
      E0CXQ6
      Conserved Domains (2) summary
      cd08684
      Location:239 → 341
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:352 → 486
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    6. XM_006516306.2 → XP_006516369.1  tandem C2 domains nuclear protein isoform X3

      Conserved Domains (2) summary
      cd08684
      Location:57 → 159
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cl14603
      Location:170 → 304
      C2; C2 domain

    7. XM_006516305.3 → XP_006516368.1  tandem C2 domains nuclear protein isoform X2

      Conserved Domains (2) summary
      cd08684
      Location:109 → 211
      C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
      cd08692
      Location:222 → 356
      C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

    RNA

    1. XR_001780495.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001286364.1: Suppressed sequence

      Description
      NM_001286364.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XT6.2 GenPept UniProtKB/Swiss-Prot:Q91XT6

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