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    Sec23ip Sec23 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 207352, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sec23ipprovided by MGI
    Official Full Name
    Sec23 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:2450915
    See related
    Ensembl:ENSMUSG00000055319 AllianceGenome:MGI:2450915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p125; D7Ertd373e
    Summary
    Predicted to enable phospholipase activity. Acts upstream of or within acrosome assembly and single fertilization. Located in cis-Golgi network; endoplasmic reticulum exit site; and perinuclear endoplasmic reticulum. Orthologous to human SEC23IP (SEC23 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.2), thymus adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 70.51 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (128346667..128386560)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128744862..128784836)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase F Neighboring gene pentatricopeptide repeat domain 3 pseudogene Neighboring gene minichromosome maintenance complex binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3757 Neighboring gene STARR-seq mESC enhancer starr_20212 Neighboring gene STARR-seq mESC enhancer starr_20213 Neighboring gene STARR-seq mESC enhancer starr_20214 Neighboring gene predicted gene, 39093 Neighboring gene predicted gene, 32884 Neighboring gene STARR-seq mESC enhancer starr_20215

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells. Aghazadeh Y, et al. Endocrinology, 2020 Feb 1. PMID 31875919, Free PMC Article
    2. p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis. Arimitsu N, et al. FEBS Lett, 2011 Jul 21. PMID 21640725
    3. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article
    4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. involved in cholesterol trafficking to supply cholesterol for acute steroidogenesis through its interactions with 14-3-3gamma
      Title: Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells.
    2. These results suggest that p125/Sec23-interacting protein plays an important role in spermiogenesis.
      Title: p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SEC23-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029982.3 → NP_001025153.2  SEC23-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001025153.2

      Status: VALIDATED

      Source sequence(s)
      AC136741
      Consensus CDS
      CCDS21900.1
      UniProtKB/TrEMBL
      G3X928, Q4G0C0
      Related
      ENSMUSP00000035610.9, ENSMUST00000042942.10
      Conserved Domains (3) summary
      smart00454
      Location:649 → 700
      SAM; Sterile alpha motif
      pfam02862
      Location:780 → 986
      DDHD; DDHD domain
      cl15755
      Location:634 → 702
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_001420513.1 → NP_001407442.1  SEC23-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC136741

    3. NM_001420514.1 → NP_001407443.1  SEC23-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC136741

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      128346667..128386560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZC7.2 GenPept UniProtKB/Swiss-Prot:Q6NZC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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