Slc29a4 solute carrier family 29 (nucleoside transporters), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc29a4provided by MGI
Official Full Name: solute carrier family 29 (nucleoside transporters), member 4provided by MGI
Primary source: MGI:MGI:2385330
See related: Ensembl:ENSMUSG00000050822 AllianceGenome:MGI:2385330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ENT4; PMAT; mENT4; mPMAT
Summary: Enables several functions, including monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including monoamine transport; toxin transport; and xenobiotic transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in brain and male reproductive gland or organ. Orthologous to human SLC29A4 (solute carrier family 29 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 34.0), CNS E14 (RPKM 29.0) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 81.56 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (142678226..142708245)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (142692478..142722490)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterotypic Stressors Unmask Behavioral Influences of PMAT Deficiency in Mice.
Title: Heterotypic Stressors Unmask Behavioral Influences of PMAT Deficiency in Mice.
Uncovering Functional Contributions of PMAT (Slc29a4) to Monoamine Clearance Using Pharmacobehavioral Tools.
Title: Uncovering Functional Contributions of PMAT (Slc29a4) to Monoamine Clearance Using Pharmacobehavioral Tools.
Deletion of murine slc29a4 modifies vascular responses to adenosine and 5-hydroxytryptamine in a sexually dimorphic manner.
Title: Deletion of murine slc29a4 modifies vascular responses to adenosine and 5-hydroxytryptamine in a sexually dimorphic manner.
PMAT is a major transporter for choroid plexus uptake of bioactive amines and xenobiotic cations.
Title: Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene.
ENT4, in addition to playing roles in cardiac serotonin transport, contributes to the regulation of extracellular adenosine concentrations, in particular under the acidotic conditions associated with ischemia.
Title: Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547070

Slc29a4 (e-PCR), detects polymorphism
- UniSTS:547070

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoamine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neurotransmitter transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables organic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables toxin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenosine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in adenosine transport	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in epinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in epinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in histamine transport	ISO Inferred from Sequence Orthology more info
involved_in histamine uptake	ISO Inferred from Sequence Orthology more info
involved_in monoamine transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine uptake	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in norepinephrine uptake	ISO Inferred from Sequence Orthology more info
involved_in nucleoside transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in organic acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin uptake	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: equilibrative nucleoside transporter 4

Names: plasma membrane monoamine transporter; solute carrier family 29 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424729.1 → NP_001411658.1 equilibrative nucleoside transporter 4 isoform 1

Status: VALIDATED

Source sequence(s)

AC240265

UniProtKB/Swiss-Prot

Q8R139
NM_001424730.1 → NP_001411659.1 equilibrative nucleoside transporter 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC240265
NM_001424731.1 → NP_001411660.1 equilibrative nucleoside transporter 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC240265
NM_146257.3 → NP_666369.1 equilibrative nucleoside transporter 4 isoform 1

See identical proteins and their annotated locations for NP_666369.1

Status: VALIDATED

Source sequence(s)

AC240265

Consensus CDS

CCDS39364.1

UniProtKB/Swiss-Prot

Q8R139

Related

ENSMUSP00000059896.8, ENSMUST00000058418.8

Conserved Domains (1) summary

cl15430
Location:75 → 498

Nucleoside_tran; Nucleoside transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

142678226..142708245

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165132.1 → XP_036021025.1 equilibrative nucleoside transporter 4 isoform X2

Conserved Domains (1) summary

cl15430
Location:29 → 343

Nucleoside_tran; Nucleoside transporter