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    Map3k9 mitogen-activated protein kinase kinase kinase 9 [ Mus musculus (house mouse) ]

    Gene ID: 338372, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Map3k9provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 9provided by MGI
    Primary source
    MGI:MGI:2449952
    See related
    Ensembl:ENSMUSG00000042724 AllianceGenome:MGI:2449952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlk1; Prke1; E130314H24Rik
    Summary
    Predicted to enable JUN kinase kinase kinase activity. Predicted to be involved in cell death; positive regulation of apoptotic process; and protein autophosphorylation. Predicted to act upstream of or within apoptotic process and phosphorylation. Orthologous to human MAP3K9 (mitogen-activated protein kinase kinase kinase 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 6.1), CNS E18 (RPKM 6.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 37.91 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81761724..81828010, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81714950..81781170, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32677 Neighboring gene tetratricopeptide repeat domain 9 Neighboring gene ragulator complex protein LAMTOR2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4034 Neighboring gene STARR-seq mESC enhancer starr_32680 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:82893600-82893709 Neighboring gene predicted gene, 30706 Neighboring gene STARR-seq mESC enhancer starr_32681 Neighboring gene pecanex 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:83072406-83072559 Neighboring gene STARR-seq mESC enhancer starr_32682

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype. Bisson N, et al. Cell Cycle, 2008 Apr 1. PMID 18414056
    2. Modulation of SRF-dependent gene expression by association of SPT16 with MKL1. Kihara T, et al. Exp Cell Res, 2008 Feb 1. PMID 18036521
    3. MAP3Ks as central regulators of cell fate during development. Craig EA, et al. Dev Dyn, 2008 Nov. PMID 18855897
    4. Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Wajapeyee N, et al. Genes Dev, 2013 Oct 15. PMID 24105743, Free PMC Article
    5. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9.
      Title: MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9.
    2. There is extensive functional redundancy between MLK1 and MLK2, and the other member of the family, MLK3, none of which are required for survival in mouse.
      Title: Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.
    3. These results show that the expression of nucleosomal SRF-dependent genes, including the SMC gene, is activated by MKL1 via activation of SRF and recruitment of the FACT complex.
      Title: Modulation of SRF-dependent gene expression by association of SPT16 with MKL1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 9
    NP_001167578.1
    NP_796369.2
    XP_006516099.1
    XP_006516100.1
    XP_017170611.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001174107.1 → NP_001167578.1  mitogen-activated protein kinase kinase kinase 9 isoform 1

      See identical proteins and their annotated locations for NP_001167578.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125351, AK053843, AK155677
      Consensus CDS
      CCDS49104.1
      UniProtKB/Swiss-Prot
      E9QLZ4, Q3U1V8, Q8BIG8
      Related
      ENSMUSP00000041819.8, ENSMUST00000035987.9
      Conserved Domains (3) summary
      smart00219
      Location:137 → 396
      TyrKc; Tyrosine kinase, catalytic domain
      cd12059
      Location:49 → 106
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14145
      Location:130 → 399
      STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

    2. NM_177395.5 → NP_796369.2  mitogen-activated protein kinase kinase kinase 9 isoform 2

      See identical proteins and their annotated locations for NP_796369.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
      Source sequence(s)
      AC125351, AK053843, AK155677
      UniProtKB/Swiss-Prot
      Q3U1V8
      Related
      ENSMUST00000223292.2
      Conserved Domains (3) summary
      cd12059
      Location:49 → 106
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      smart00221
      Location:137 → 396
      STYKc; Protein kinase; unclassified specificity
      cd14145
      Location:130 → 399
      STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81761724..81828010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315122.3 → XP_017170611.1  mitogen-activated protein kinase kinase kinase 9 isoform X1

      Conserved Domains (2) summary
      cd12059
      Location:49 → 106
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14145
      Location:130 → 399
      STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

    2. XM_006516036.5 → XP_006516099.1  mitogen-activated protein kinase kinase kinase 9 isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VKX4
      Related
      ENSMUSP00000152201.2, ENSMUST00000222322.2
      Conserved Domains (2) summary
      cd12059
      Location:49 → 106
      SH3_MLK1-3; Src Homology 3 domain of Mixed Lineage Kinases 1, 2, and 3
      cd14145
      Location:130 → 399
      STKc_MLK1; Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1

    3. XM_006516037.4 → XP_006516100.1  mitogen-activated protein kinase kinase kinase 9 isoform X3

      UniProtKB/TrEMBL
      Q8K2L2
      Conserved Domains (3) summary
      PHA03247
      Location:547 → 808
      PHA03247; large tegument protein UL36; Provisional
      cl21453
      Location:27 → 162
      PKc_like; Protein Kinases, catalytic domain
      cl27170
      Location:183 → 265
      DUF460; Protein of unknown function (DUF460)

    RNA

    1. XR_004937523.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U1V8.2 GenPept UniProtKB/Swiss-Prot:Q3U1V8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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