Kif6 kinesin family member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif6provided by MGI
Official Full Name: kinesin family member 6provided by MGI
Primary source: MGI:MGI:1098238
See related: Ensembl:ENSMUSG00000023999 AllianceGenome:MGI:1098238
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D130004B10Rik; D130084M03Rik
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in lateral ventricle choroid plexus and metencephalon part of 4th ventricle choroid plexus. Orthologous to human KIF6 (kinesin family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 1.1), heart adult (RPKM 0.4) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 25.78 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (49922121..50216875)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (49615098..49909847)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that dysfunction of Kif6 is linked to other more complex biological/biochemical parameters or is unlikely to be of material consequence in cardiac function.
Title: No evidence for cardiac dysfunction in Kif6 mutant mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

D17Mit106 (e-PCR), detects polymorphism
- UniSTS:127943

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF6

Names: kinesin 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177052.3 → NP_796026.2 kinesin-like protein KIF6

Status: VALIDATED

Source sequence(s)

AC114824, AC124748, AK084082

Consensus CDS

CCDS50144.1

UniProtKB/TrEMBL

E9PX57

Related

ENSMUSP00000124674.2, ENSMUST00000162854.2

Conserved Domains (3) summary

cd01375
Location:5 → 343

KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup

pfam00225
Location:11 → 345

Kinesin; Kinesin motor domain

cl00920
Location:350 → 408

Cob_adeno_trans; Cobalamin adenosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

49922121..50216875

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524391.5 → XP_006524454.1 kinesin-like protein KIF6 isoform X1

Conserved Domains (2) summary

cd01375
Location:5 → 343

KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup

cl00920
Location:350 → 408

Cob_adeno_trans; Cobalamin adenosyltransferase
XM_006524393.5 → XP_006524456.1 kinesin-like protein KIF6 isoform X3

Conserved Domains (2) summary

cl22853
Location:5 → 343

Motor_domain; Myosin and Kinesin motor domain

cl00920
Location:350 → 408

Cob_adeno_trans; Cobalamin adenosyltransferase
XM_011246494.3 → XP_011244796.1 kinesin-like protein KIF6 isoform X4

Conserved Domains (3) summary

TIGR00618
Location:301 → 606

sbcc; exonuclease SbcC

cl22853
Location:98 → 270

Motor_domain; Myosin and Kinesin motor domain

cl00920
Location:277 → 335

Cob_adeno_trans; Cobalamin adenosyltransferase
XM_017317502.3 → XP_017172991.1 kinesin-like protein KIF6 isoform X2

Conserved Domains (2) summary

cl22853
Location:10 → 184

Motor_domain; Myosin and Kinesin motor domain

cl00920
Location:191 → 249

Cob_adeno_trans; Cobalamin adenosyltransferase