Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ywhazprovided by MGI
Official Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideprovided by MGI
Primary source: MGI:MGI:109484
See related: Ensembl:ENSMUSG00000022285 AllianceGenome:MGI:109484
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 14-3-3zeta; 1110013I11Rik
Summary: Enables protein domain specific binding activity. Involved in several processes, including respiratory system process; synaptic target recognition; and tube morphogenesis. Acts upstream of or within ERK1 and ERK2 cascade; protein targeting; and regulation of cell death. Located in hippocampal mossy fiber to CA3 synapse and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Used to study schizophrenia. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 171.9), cortex adult (RPKM 135.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 14.56 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (36770505..36803228, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (36770261..36802984, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3zeta.
Title: IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ.
High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis.
Title: High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis.
14-3-3zeta inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis.
Title: 14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis.
YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m[6]A-mediated YWHAZ stability.
Title: YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m(6)A-mediated YWHAZ stability.
14-3-3zeta Constrains insulin secretion by regulating mitochondrial function in pancreatic beta cells.
Title: 14-3-3ζ Constrains insulin secretion by regulating mitochondrial function in pancreatic β cells.
Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta protein and represses lung cancer metastasis.
Title: Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.
14-3-3zeta mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance.
Title: 14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance.
Reducing 14-3-3zeta expression influences adipocyte maturity and impairs function.
Title: Reducing 14-3-3ζ expression influences adipocyte maturity and impairs function.
It has been proposed that MsrA-dependent 14-3-3 zeta ubiquitination affects the regulation of alpha synuclein degradation and dopamine synthesis in the brain.
Title: Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14-3-3 protein isotypes in brain.
DEX can increase IOP in mouse eyes and concurrently downregulate 14-3-3 zeta protein expression in mouse TM
Title: Expression of 14-3-3 Zeta Protein in Dexamethasone-Treated Mice and Human TM-1 Cells.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3)
Targeted (3)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI596267 (e-PCR)
- UniSTS:180745

Ywhaz (e-PCR), detects polymorphism
- UniSTS:507439

RH136575 (e-PCR)
- UniSTS:210555

Ywhaz (e-PCR), detects polymorphism
- UniSTS:144816

D15Abb1e (e-PCR), detects polymorphism
- UniSTS:142002

PMC150726P3 (e-PCR)
- UniSTS:271075

NoName (e-PCR)
- UniSTS:237283

NoName (e-PCR)
- UniSTS:237284

Ywhaz (e-PCR), detects polymorphism
- UniSTS:527611

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphoserine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi reassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in establishment of Golgi localization	ISO Inferred from Sequence Orthology more info
involved_in histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in respiratory system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in synaptic target recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tube formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tube formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 14-3-3 protein zeta/delta

Names: 14-3-3 zeta; KCIP-1; SEZ-2; protein kinase C inhibitor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253805.1 → NP_001240734.1 14-3-3 protein zeta/delta isoform 1

See identical proteins and their annotated locations for NP_001240734.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.

Source sequence(s)

AA277102, AK003664, AK083368, BB652039, BC050891, BQ833188

Consensus CDS

CCDS27432.1

UniProtKB/Swiss-Prot

P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1

Related

ENSMUSP00000105990.2, ENSMUST00000110361.8

Conserved Domains (1) summary

cd10022
Location:2 → 230

14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
NM_001253806.1 → NP_001240735.1 14-3-3 protein zeta/delta isoform 1

See identical proteins and their annotated locations for NP_001240735.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.

Source sequence(s)

AA277102, AK003664, BC050891, BQ833188, CF172373

Consensus CDS

CCDS27432.1

UniProtKB/Swiss-Prot

P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1

Conserved Domains (1) summary

cd10022
Location:2 → 230

14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
NM_001253807.1 → NP_001240736.1 14-3-3 protein zeta/delta isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, which results in a downstream AUG start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AC138604

Conserved Domains (1) summary

cl02098
Location:1 → 209

14-3-3; 14-3-3 domain
NM_001356569.1 → NP_001343498.1 14-3-3 protein zeta/delta isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5 encode the same isoform 1.

Source sequence(s)

AC138604

Consensus CDS

CCDS27432.1

UniProtKB/Swiss-Prot

P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1

Conserved Domains (1) summary

cd10022
Location:2 → 230

14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
NM_011740.3 → NP_035870.1 14-3-3 protein zeta/delta isoform 1

See identical proteins and their annotated locations for NP_035870.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-3 and 5 encode the same isoform 1.

Source sequence(s)

AC138604, AK150381, BB652039, BQ833188

Consensus CDS

CCDS27432.1

UniProtKB/Swiss-Prot

P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1

Related

ENSMUSP00000022894.8, ENSMUST00000022894.14

Conserved Domains (1) summary

cd10022
Location:2 → 230

14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

36770505..36803228 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248527.2 → XP_030104387.1 14-3-3 protein zeta/delta isoform X1

UniProtKB/Swiss-Prot

P35215, P63101, P70197, P97286, Q3TSF1, Q5EBQ1

Related

ENSMUSP00000105991.4, ENSMUST00000110362.4

Conserved Domains (1) summary

cd10022
Location:2 → 230

14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein