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    Pcdhb16 protocadherin beta 16 [ Mus musculus (house mouse) ]

    Gene ID: 93887, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pcdhb16provided by MGI
    Official Full Name
    protocadherin beta 16provided by MGI
    Primary source
    MGI:MGI:2136752
    See related
    Ensembl:ENSMUSG00000047910 AllianceGenome:MGI:2136752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcdhb8; PcdhbP
    Summary
    Predicted to be involved in cell adhesion. Located in photoreceptor connecting cilium; photoreceptor disc membrane; and postsynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human PCDHB13 (protocadherin beta 13) and PCDHB8 (protocadherin beta 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    18 B3; 18 19.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37610821..37616091)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37477768..37483038)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin beta 14 Neighboring gene protocadherin beta 15 Neighboring gene protocadherin beta 17 Neighboring gene protocadherin beta 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. Hirano K, et al. Front Mol Neurosci, 2012. PMID 22969705, Free PMC Article
    2. Protocadherins. Frank M, et al. Curr Opin Cell Biol, 2002 Oct. PMID 12231349
    3. Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. Hasegawa S, et al. Front Mol Neurosci, 2016. PMID 28066179, Free PMC Article
    4. A unique role of cohesin-SA1 in gene regulation and development. Remeseiro S, et al. EMBO J, 2012 May 2. PMID 22415368, Free PMC Article
    5. A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development. Osipovich AB, et al. Development, 2021 Mar 21. PMID 33653874, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synapse assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in photoreceptor connecting cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor disc membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protocadherin beta 16
    Names
    Protocadherin-betaP
    cell-cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053141.3 → NP_444371.3  protocadherin beta 16 precursor

      See identical proteins and their annotated locations for NP_444371.3

      Status: VALIDATED

      Source sequence(s)
      AK036829, BC116625, BP762533, CJ182908
      Consensus CDS
      CCDS29182.1
      UniProtKB/TrEMBL
      Q14BM8, Q8CB45, Q91Y03
      Related
      ENSMUSP00000056347.6, ENSMUST00000051442.7
      Conserved Domains (3) summary
      cd11304
      Location:248 → 344
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:32 → 113
      Cadherin_2; Cadherin-like
      pfam16492
      Location:687 → 770
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      37610821..37616091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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