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    Ggact gamma-glutamylamine cyclotransferase [ Mus musculus (house mouse) ]

    Gene ID: 223267, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Ggactprovided by MGI
    Official Full Name
    gamma-glutamylamine cyclotransferaseprovided by MGI
    Primary source
    MGI:MGI:2385008
    See related
    Ensembl:ENSMUSG00000041625 AllianceGenome:MGI:2385008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A2ld1
    Summary
    Predicted to enable gamma-glutamylaminecyclotransferase activity. Predicted to be involved in cellular modified amino acid catabolic process. Predicted to be active in cytosol. Orthologous to human GGACT (gamma-glutamylamine cyclotransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 25.9), liver adult (RPKM 22.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 E5; 14 66.04 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (123128272..123151173, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (122890860..122913413, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene propionyl-Coenzyme A carboxylase, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E10845 Neighboring gene predicted gene, 46487 Neighboring gene STARR-seq mESC enhancer starr_37780 Neighboring gene STARR-seq mESC enhancer starr_37781 Neighboring gene STARR-seq mESC enhancer starr_37782 Neighboring gene STARR-seq mESC enhancer starr_37783 Neighboring gene STARR-positive B cell enhancer mm9_chr14:123229731-123230031 Neighboring gene predicted gene, 53848 Neighboring gene RIKEN cDNA 4930594M22 gene Neighboring gene predicted gene, 46488 Neighboring gene STARR-seq mESC enhancer starr_37784 Neighboring gene transmembrane and tetratricopeptide repeat containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E8582 Neighboring gene predicted gene, 57613

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC7867

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-glutamylaminecyclotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular modified amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-glutamylaminecyclotransferase
    Names
    AIG2-like domain 1
    AIG2-like domain-containing protein 1
    NP_001412730.1
    NP_001412731.1
    NP_001412732.1
    NP_001412736.1
    NP_001412737.1
    NP_001412738.1
    NP_001412739.1
    NP_001412740.1
    NP_663441.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425801.1 → NP_001412730.1  gamma-glutamylaminecyclotransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154499

    2. NM_001425802.1 → NP_001412731.1  gamma-glutamylaminecyclotransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154499

    3. NM_001425803.1 → NP_001412732.1  gamma-glutamylaminecyclotransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154499

    4. NM_001425807.1 → NP_001412736.1  gamma-glutamylaminecyclotransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154499
      UniProtKB/Swiss-Prot
      Q66JP0, Q923B0

    5. NM_001425808.1 → NP_001412737.1  gamma-glutamylaminecyclotransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154499
      UniProtKB/Swiss-Prot
      Q66JP0, Q923B0

    6. NM_001425809.1 → NP_001412738.1  gamma-glutamylaminecyclotransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154499
      UniProtKB/Swiss-Prot
      Q66JP0, Q923B0

    7. NM_001425810.1 → NP_001412739.1  gamma-glutamylaminecyclotransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154499
      UniProtKB/Swiss-Prot
      Q66JP0, Q923B0

    8. NM_001425811.1 → NP_001412740.1  gamma-glutamylaminecyclotransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154499
      UniProtKB/Swiss-Prot
      Q66JP0, Q923B0

    9. NM_145466.3 → NP_663441.1  gamma-glutamylaminecyclotransferase isoform 3

      See identical proteins and their annotated locations for NP_663441.1

      Status: VALIDATED

      Source sequence(s)
      AC154499
      Consensus CDS
      CCDS27351.1
      UniProtKB/Swiss-Prot
      Q66JP0, Q923B0
      UniProtKB/TrEMBL
      E0CX39
      Related
      ENSMUSP00000037278.6, ENSMUST00000038075.12
      Conserved Domains (1) summary
      pfam06094
      Location:4 → 134
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    RNA

    1. NR_189593.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154499

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      123128272..123151173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923B0.1 GenPept UniProtKB/Swiss-Prot:Q923B0

    Gene LinkOut

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