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    Nob1 NIN1/RPN12 binding protein 1 homolog [ Mus musculus (house mouse) ]

    Gene ID: 67619, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nob1provided by MGI
    Official Full Name
    NIN1/RPN12 binding protein 1 homologprovided by MGI
    Primary source
    MGI:MGI:1914869
    See related
    Ensembl:ENSMUSG00000003848 AllianceGenome:MGI:1914869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ART-4; Nob1p; Psmd8bp1; 1700021I09Rik
    Summary
    Predicted to enable endoribonuclease activity. Acts upstream of or within visual perception. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of preribosome, small subunit precursor. Is expressed in nervous system and neural retina. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 29.2), limb E14.5 (RPKM 26.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 D3; 8 54.12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108139121..108151670, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107412489..107425038, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells 5 Neighboring gene predicted gene, 51546 Neighboring gene STARR-seq mESC enhancer starr_22601 Neighboring gene NAD(P)H dehydrogenase, quinone 1 Neighboring gene STARR-positive B cell enhancer ABC_E8262 Neighboring gene STARR-positive B cell enhancer ABC_E1107 Neighboring gene STARR-seq mESC enhancer starr_22606 Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene predicted gene, 39241 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nob1p is required for cleavage of the 3' end of 18S rRNA. Fatica A, et al. Mol Cell Biol, 2003 Mar. PMID 12588997, Free PMC Article
    2. Rod-driven OFF pathway responses in the distal retina: dark-adapted flicker electroretinogram in mouse. Lei B. PLoS One, 2012. PMID 22937111, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118441, MGC144649, MGC144650

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within maturation of SSU-rRNA ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within ribosomal small subunit biogenesis ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in nucleolus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein NOB1
    Names
    PSMD8 binding protein 1
    nin one binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026277.3 → NP_080553.1  RNA-binding protein NOB1

      See identical proteins and their annotated locations for NP_080553.1

      Status: VALIDATED

      Source sequence(s)
      AC158364
      Consensus CDS
      CCDS22649.1
      UniProtKB/Swiss-Prot
      Q7TPR3, Q8BW10, Q9CRD7
      UniProtKB/TrEMBL
      Q148S3
      Related
      ENSMUSP00000003946.9, ENSMUST00000003946.9
      Conserved Domains (4) summary
      cd09876
      Location:7 → 115
      PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
      COG1439
      Location:8 → 292
      Nob1; rRNA maturation endonuclease Nob1 [Translation, ribosomal structure and biogenesis]
      pfam15017
      Location:135 → 211
      AF1Q; Drug resistance and apoptosis regulator
      pfam08772
      Location:251 → 323
      NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      108139121..108151670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BW10.1 GenPept UniProtKB/Swiss-Prot:Q8BW10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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