Adcy10 adenylate cyclase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcy10provided by MGI
Official Full Name: adenylate cyclase 10provided by MGI
Primary source: MGI:MGI:2660854
See related: Ensembl:ENSMUSG00000026567 AllianceGenome:MGI:2660854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sAC; Sacy; 4931412F17; 4930431D04Rik
Summary: Predicted to enable several functions, including ATPase binding activity; bicarbonate binding activity; and manganese ion binding activity. Predicted to be involved in several processes, including cAMP biosynthetic process; epithelial cilium movement involved in extracellular fluid movement; and positive regulation of apoptotic process. Located in apical plasma membrane. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human ADCY10 (adenylate cyclase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 24.0) See more
Orthologs: human all
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Genomic context

Location:: 1 H2.3; 1 72.83 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (165309114..165404347)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (165483518..165576778)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis.
Title: Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis.
Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.
Title: Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.
This study showed that sAC is essential for lysosomal acidification in addition to its other roles in cell physiology.
Title: Soluble adenylyl cyclase is essential for proper lysosomal acidification.
sAC is a regulator of gene expression involved in aldosterone signaling and an important regulator of endothelial stiffness.
Title: Soluble adenylyl cyclase in vascular endothelium: gene expression control of epithelial sodium channel-α, Na+/K+-ATPase-α/β, and mineralocorticoid receptor.
cAMP pathways are compartmentalized in sperm, with Gs proteins and transmembrane adenyl cyclase in the head and Adcy10 and PKA in the flagellum.
Title: Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.
sAC is necessary for normal glucose-stimulated insulin secretion in vitro and in vivo.
Title: CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.
Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.
Title: Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.
Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation.
Title: Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation.
External Ca2+ binds an unidentified extracellular protein that is required for HCO3(-) to engage cyclic AMP-mediated activation of motility.
Title: External Ca2+ acts upstream of adenylyl cyclase SACY in the bicarbonate signaled activation of sperm motility.
These results suggest that NO regulation of MMP-9 secreted from macrophages may occur chemically by reactive nitrogen species-mediated protein modification, biologically through soluble guanylyl-cyclase.
Title: Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adcy10 (e-PCR), detects polymorphism
- UniSTS:527118

Adcy10 (e-PCR), detects polymorphism
- UniSTS:527119

Adcy10 (e-PCR), detects polymorphism
- UniSTS:546631

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
enables bicarbonate binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to inorganic substance	ISO Inferred from Sequence Orthology more info
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in epithelial cilium movement involved in extracellular fluid movement	ISO Inferred from Sequence Orthology more info
involved_in glucose catabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ATP transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in neuron projection maintenance	ISO Inferred from Sequence Orthology more info
involved_in neuron projection retraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycogen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte end-foot	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in central region of growth cone	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
colocalizes_with motile cilium	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylate cyclase type 10

Names: germ cell soluble adenylyl cyclase; testicular soluble adenylyl cyclase

NP_001344356.1

EC 4.6.1.1

NP_766617.2

EC 4.6.1.1

XP_006496930.1

EC 4.6.1.1

XP_011237125.1

EC 4.6.1.1

XP_017176545.1

EC 4.6.1.1

XP_017176549.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357427.1 → NP_001344356.1 adenylate cyclase type 10 isoform 2

Status: VALIDATED

Source sequence(s)

AC102776, AC162789
NM_173029.3 → NP_766617.2 adenylate cyclase type 10 isoform 1

See identical proteins and their annotated locations for NP_766617.2

Status: VALIDATED

Source sequence(s)

AK029849, BC138448

Consensus CDS

CCDS35756.1

UniProtKB/Swiss-Prot

B2RRJ9, Q3V0F8, Q8C0T9

Related

ENSMUSP00000027852.9, ENSMUST00000027852.15

Conserved Domains (2) summary

cd07302
Location:40 → 214

CHD; cyclase homology domain

COG3899
Location:485 → 959

COG3899; Predicted ATPase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

165309114..165404347

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321056.3 → XP_017176545.1 adenylate cyclase type 10 isoform X1

UniProtKB/Swiss-Prot

B2RRJ9, Q3V0F8, Q8C0T9

Conserved Domains (2) summary

cd07302
Location:40 → 214

CHD; cyclase homology domain

COG3899
Location:485 → 959

COG3899; Predicted ATPase [General function prediction only]
XM_017321060.2 → XP_017176549.1 adenylate cyclase type 10 isoform X2

UniProtKB/TrEMBL

E9Q9T4

Related

ENSMUSP00000107066.2, ENSMUST00000111439.8

Conserved Domains (2) summary

cd07302
Location:40 → 214

CHD; cyclase homology domain

COG3899
Location:485 → 959

COG3899; Predicted ATPase [General function prediction only]
XM_006496867.1 → XP_006496930.1 adenylate cyclase type 10 isoform X1

See identical proteins and their annotated locations for XP_006496930.1

UniProtKB/Swiss-Prot

B2RRJ9, Q3V0F8, Q8C0T9

Conserved Domains (2) summary

cd07302
Location:40 → 214

CHD; cyclase homology domain

COG3899
Location:485 → 959

COG3899; Predicted ATPase [General function prediction only]
XM_011238823.3 → XP_011237125.1 adenylate cyclase type 10 isoform X3