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    Nat8f4 N-acetyltransferase 8 (GCN5-related) family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 75541, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Nat8f4provided by MGI
    Official Full Name
    N-acetyltransferase 8 (GCN5-related) family member 4provided by MGI
    Primary source
    MGI:MGI:1922791
    See related
    Ensembl:ENSMUSG00000068299 AllianceGenome:MGI:1922791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700019G17Rik
    Summary
    Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Predicted to be involved in several processes, including negative regulation of apoptotic process; peptide metabolic process; and peptidyl-lysine N6-acetylation. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be integral component of membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 5.1), liver adult (RPKM 3.8) and 21 other tissues See more
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    Genomic context

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    Location:
    6 C3; 6 37.52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85876032..85881920, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85899050..85909315, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16510 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 2 Neighboring gene STARR-seq mESC enhancer starr_16511 Neighboring gene 60S ribosomal protein L23a-like Neighboring gene STARR-seq mESC enhancer starr_16512 Neighboring gene STARR-positive B cell enhancer ABC_E11321 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 1 Neighboring gene Tp53rk binding protein Neighboring gene syndecan binding protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis. Nakajima R, et al. PLoS One, 2016. PMID 27649575, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-S-conjugate N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyltransferase family 8 member 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145895.1 → NP_001139367.1  N-acetyltransferase family 8 member 4 isoform 2

      See identical proteins and their annotated locations for NP_001139367.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR segment and lacks an internal coding segment, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC161888
      Consensus CDS
      CCDS51831.1
      UniProtKB/TrEMBL
      E0CYM0
      Related
      ENSMUSP00000124071.2, ENSMUST00000159755.8

    2. NM_029331.3 → NP_083607.3  N-acetyltransferase family 8 member 4 isoform 1

      See identical proteins and their annotated locations for NP_083607.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC161888
      Consensus CDS
      CCDS39540.1
      UniProtKB/TrEMBL
      G5E8L3, Q8CID2
      Related
      ENSMUSP00000093430.4, ENSMUST00000095757.4
      Conserved Domains (1) summary
      pfam00583
      Location:82 → 192
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      85876032..85881920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506720.5 → XP_006506783.1  N-acetyltransferase family 8 member 4 isoform X1

      See identical proteins and their annotated locations for XP_006506783.1

      UniProtKB/TrEMBL
      G5E8L3, Q8CID2
      Conserved Domains (1) summary
      pfam00583
      Location:82 → 192
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein Strain
    Heading Accession and Version

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