H3c7 H3 clustered histone 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H3c7provided by MGI
Official Full Name: H3 clustered histone 7provided by MGI
Primary source: MGI:MGI:2448329
See related: Ensembl:ENSMUSG00000100210 AllianceGenome:MGI:2448329
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H3c2; H3c3; H3c4; H3c6; H3c13; H3c14; H3c15; Hist1; H3.2-221; Hist1h3f
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
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Genomic context

Location:: 13 A3.1; 13 9.78 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (23728222..23729124)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (23544052..23544954)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone H3 activates caspase-1 and promotes proliferation and metastasis in hepatocellular carcinoma.
Title: Histone H3 activates caspase-1 and promotes proliferation and metastasis in hepatocellular carcinoma.
Asymmetrical deposition and modification of histone H3 variants are essential for zygote development.
Title: Asymmetrical deposition and modification of histone H3 variants are essential for zygote development.
SLBP overexpression caused by Fbxo30 depletion results in a remarkable overload of histone H3 on chromosomes that excessively condenses chromosomes and inhibits chromosome segregation. The finding uncovers an unidentified pathway-controlling chromosome segregation and cell progress.
Title: Fbxo30 regulates chromosome segregation of oocyte meiosis.
The data indicate that brachyury mediates acetylated H3K27 recruitment through a physical interaction with p300 during the mouse mesoderm development.
Title: BRACHYURY directs histone acetylation to target loci during mesoderm development.
Results suggest a critical role of histone-lysine N-methyltransferase Nsd2-mediated histone H3K36 methylation in adipose tissue development and function.
Title: Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.
Histone H3.3K27M and Trp53 loss and PDGFRA overexpression accelerates disease onset and increases tumor invasion.
Title: H3.3(K27M) Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.
Histone H3 arginine 2 dimethylation lysine 4 trimethylation, not simply H3lysine 4 trimethylation alone, is the mark of active promoters
Title: Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.
Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network.
Title: Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network.
Increased levels of decondensed chromatin in both normal progenitor cells and cancer cells are associated with global loss of H3K27me3, which is linked to MYC overexpression.
Title: Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer.
Bmi1, which methylate H3K27, were present on the HSV-1 genome during latency.
Title: The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490537

NoName (e-PCR)
- UniSTS:485229

Hist1 (e-PCR), detects polymorphism
- UniSTS:143347

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H3.2

Names: H3-clustered histone 13; H3-clustered histone 14; H3-clustered histone 15; H3-clustered histone 2; H3-clustered histone 3; H3-clustered histone 4; H3-clustered histone 6; histone 1, H3f; histone H3; histone cluster 1, H3f; histone gene complex 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.