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    Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 [ Mus musculus (house mouse) ]

    Gene ID: 108150, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Galnt7provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 7provided by MGI
    Primary source
    MGI:MGI:1349449
    See related
    Ensembl:ENSMUSG00000031608 AllianceGenome:MGI:1349449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human GALNT7 (polypeptide N-acetylgalactosaminyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 6.3), placenta adult (RPKM 5.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B2; 8 29.92 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (57976859..58106089, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (57523825..57653055, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2500002B13 gene Neighboring gene STARR-seq mESC enhancer starr_21528 Neighboring gene STARR-positive B cell enhancer ABC_E1755 Neighboring gene STARR-seq mESC enhancer starr_21531 Neighboring gene STARR-seq mESC enhancer starr_21533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:60058653-60058919 Neighboring gene predicted gene 6012 Neighboring gene predicted gene, 51574 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 25379 Neighboring gene high mobility group box 2 Neighboring gene expressed sequence AW046200 Neighboring gene STARR-seq mESC enhancer starr_21537 Neighboring gene STARR-seq mESC enhancer starr_21540 Neighboring gene STARR-positive B cell enhancer ABC_E5007 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6 Neighboring gene STARR-seq mESC enhancer starr_21544 Neighboring gene predicted gene 2921 Neighboring gene STARR-seq mESC enhancer starr_21547 Neighboring gene predicted gene 15881

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase that displays glycopeptide N-acetylgalactosaminyltransferase activity. Ten Hagen KG, et al. J Biol Chem, 1999 Sep 24. PMID 10488133
    2. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. Kahai S, et al. PLoS One, 2009 Oct 21. PMID 19844573, Free PMC Article
    3. Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. Ten Hagen KG, et al. J Biol Chem, 2001 May 18. PMID 11278534
    4. Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development. Kingsley PD, et al. Glycobiology, 2000 Dec. PMID 11159923
    5. miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway. Guess MG, et al. PLoS One, 2015. PMID 25689854, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7
      Title: MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylgalactosaminyltransferase 7
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7
    UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
    galNAc-T7
    polypeptide GalNAc transferase 7
    pp-GaNTase 7
    ppGaNTase-T7
    protein-UDP acetylgalactosaminyltransferase 7
    NP_001161453.1
    NP_653332.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167981.1 → NP_001161453.1  N-acetylgalactosaminyltransferase 7 isoform 2

      See identical proteins and their annotated locations for NP_001161453.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon and lacks an alternate in-frame exon, compared to variant 1, and encodes isoform 2. Variants 1 and 2 encode proteins of identical length but use different exons to encode aa 323-383.
      Source sequence(s)
      AK033427, AK036523, AK152205, BY167413, CB524213
      Consensus CDS
      CCDS52552.1
      UniProtKB/TrEMBL
      Q3U9K4
      Related
      ENSMUSP00000105945.3, ENSMUST00000110316.3
      Conserved Domains (4) summary
      cd02510
      Location:210 → 518
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG1215
      Location:210 → 438
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      cd00161
      Location:535 → 651
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:534 → 649
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_144731.4 → NP_653332.3  N-acetylgalactosaminyltransferase 7 isoform 1

      See identical proteins and their annotated locations for NP_653332.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode proteins of identical length but use different exons to encode aa 323-383.
      Source sequence(s)
      AF349573, AK033427, AK152205, BY167413, CB524213
      Consensus CDS
      CCDS22317.1
      UniProtKB/Swiss-Prot
      Q80VA0, Q8BY62, Q8BZ70, Q8BZW0, Q91VW6, Q99MD7
      UniProtKB/TrEMBL
      Q3U9K4
      Related
      ENSMUSP00000034021.5, ENSMUST00000034021.12
      Conserved Domains (4) summary
      cd02510
      Location:210 → 518
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:210 → 444
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:535 → 651
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:534 → 649
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      57976859..58106089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VA0.2 GenPept UniProtKB/Swiss-Prot:Q80VA0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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