Prss41 serine protease 41 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss41provided by MGI
Official Full Name: serine protease 41provided by MGI
Primary source: MGI:MGI:1918253
See related: Ensembl:ENSMUSG00000024114 AllianceGenome:MGI:1918253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tessp1; Tessp-1; 4931440B09Rik
Summary: Predicted to enable sodium channel regulator activity. Predicted to act upstream of or within proteolysis. Located in plasma membrane. Is expressed in eye; heart; lung; male reproductive gland or organ; and smooth muscle tissue. Orthologous to human PRSS41 (serine protease 41). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 3.8), colon adult (RPKM 1.0) and 10 other tissues See more
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Genomic context

Location:: 17 A3.3; 17 12.09 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24055759..24063190, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (23836785..23844219, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Prss/Tessp proteases are important for the progression of meiosis at each stage.
Title: A testis-specific serine protease, Prss41/Tessp-1, is necessary for the progression of meiosis during murine in vitro spermatogenesis.
The results of this study suggest that TESSP1 is predominantly localized in the plasma membrane of spermatogonia and Sertoli cells in the basal compartment.
Title: Two distinct localization patterns of testis-specific serine protease 1 (TESSP1) in the seminiferous tubules of the mouse testis.
A novel type of serine protease, designated testis-specific serine protease 1 (TESSP-1), from the adult mouse testis was cloned.
Title: TESSP-1: a novel serine protease gene expressed in the spermatogonia and spermatocytes of adult mouse testes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

4931440B09Rik (e-PCR), detects polymorphism
- UniSTS:265690

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular organelle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease 41

Names: protease, serine 41; testis serine protease 1; testis-specific serine protease 1

NP_001405693.1

EC 3.4.21.-

NP_001405694.1

EC 3.4.21.-

NP_081920.1

EC 3.4.21.-

XP_036016678.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418764.1 → NP_001405693.1 serine protease 41 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC122821
NM_001418765.1 → NP_001405694.1 serine protease 41 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC122821

Related

ENSMUSP00000122453.2, ENSMUST00000151797.3
NM_027644.2 → NP_081920.1 serine protease 41 isoform 1 precursor

See identical proteins and their annotated locations for NP_081920.1

Status: VALIDATED

Source sequence(s)

AC122821

Consensus CDS

CCDS28466.1

UniProtKB/Swiss-Prot

Q8BX01, Q920S2

UniProtKB/TrEMBL

B9EK99

Related

ENSMUSP00000024926.8, ENSMUST00000024926.14

Conserved Domains (2) summary

smart00020
Location:52 → 289

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:53 → 290

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

24055759..24063190 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160785.1 → XP_036016678.1 serine protease 41 isoform X1

UniProtKB/TrEMBL

B9EK99

Conserved Domains (1) summary

cd00190
Location:84 → 321

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...