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    Srp19 signal recognition particle 19 [ Mus musculus (house mouse) ]

    Gene ID: 66384, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Srp19provided by MGI
    Official Full Name
    signal recognition particle 19provided by MGI
    Primary source
    MGI:MGI:1913634
    See related
    Ensembl:ENSMUSG00000014504 AllianceGenome:MGI:1913634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310020D23Rik
    Summary
    Predicted to enable 7S RNA binding activity. Predicted to contribute to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be located in nucleolus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in forelimb bud. Orthologous to human SRP19 (signal recognition particle 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 36.3), liver E14 (RPKM 32.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srp19 in Genome Data Viewer
    Location:
    18 B1; 18 18.57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34464185..34469652)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34331121..34336599)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34380446-34380555 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene APC, WNT signaling pathway regulator Neighboring gene STARR-seq mESC enhancer starr_44199 Neighboring gene predicted gene, 54017 Neighboring gene receptor accessory protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E8999 Neighboring gene polycystic kidney disease 2-like 2 Neighboring gene SET translocation pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7S RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle 19 kDa protein
    NP_079803.2
    XP_006526218.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025527.3 → NP_079803.2  signal recognition particle 19 kDa protein

      See identical proteins and their annotated locations for NP_079803.2

      Status: VALIDATED

      Source sequence(s)
      AK004118, BX529045
      Consensus CDS
      CCDS37757.1
      UniProtKB/Swiss-Prot
      Q9D7A6
      UniProtKB/TrEMBL
      Q9D104
      Related
      ENSMUSP00000072386.4, ENSMUST00000072576.10
      Conserved Domains (1) summary
      pfam01922
      Location:17 → 115
      SRP19; SRP19 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34464185..34469652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526155.2 → XP_006526218.1  signal recognition particle 19 kDa protein isoform X1

      See identical proteins and their annotated locations for XP_006526218.1

      UniProtKB/Swiss-Prot
      Q9D7A6
      UniProtKB/TrEMBL
      G5E8T3
      Related
      ENSMUSP00000112826.2, ENSMUST00000119329.8
      Conserved Domains (1) summary
      pfam01922
      Location:17 → 91
      SRP19; SRP19 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7A6.1 GenPept UniProtKB/Swiss-Prot:Q9D7A6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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