Dnajc11 DnaJ heat shock protein family (Hsp40) member C11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnajc11provided by MGI
Official Full Name: DnaJ heat shock protein family (Hsp40) member C11provided by MGI
Primary source: MGI:MGI:2443386
See related: Ensembl:ENSMUSG00000039768 AllianceGenome:MGI:2443386
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E030019A03Rik
Summary: Involved in cristae formation. Located in mitochondrial inner membrane. Is expressed in submandibular gland primordium. Orthologous to human DNAJC11 (DnaJ heat shock protein family (Hsp40) member C11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 12.4), placenta adult (RPKM 11.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 82.77 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (152018177..152066416)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (151933720..151981959)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
Title: Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
a link between DNAJC11 and neuromuscular diseases
Title: A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice.
E030019A03 is the mouse ortholog of human FLJ10737, consisting of the DnaJ domain, bipartite nuclear localization signal (NLS), FADH domain, and FEMCA domain.
Title: Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142055 (e-PCR)
- UniSTS:224045

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cristae formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cristae formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cristae formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MICOS complex	ISO Inferred from Sequence Orthology more info
part_of SAM complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dnaJ homolog subfamily C member 11

Names: DnaJ (Hsp40) homolog, subfamily C, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172704.3 → NP_766292.2 dnaJ homolog subfamily C member 11

See identical proteins and their annotated locations for NP_766292.2

Status: VALIDATED

Source sequence(s)

AK053156, BY784439, DV663024

Consensus CDS

CCDS18981.2

UniProtKB/Swiss-Prot

A2A8C9, Q5U458, Q8BP83, Q8C1Z4, Q8C6U5

Related

ENSMUSP00000051643.5, ENSMUST00000062904.11

Conserved Domains (3) summary

pfam00226
Location:14 → 79

DnaJ; DnaJ domain

pfam06936
Location:372 → 447

Selenoprotein_S; Selenoprotein S (SelS)

pfam11875
Location:417 → 549

DUF3395; Domain of unknown function (DUF3395)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

152018177..152066416

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253511.2 → XP_030109371.1 dnaJ homolog subfamily C member 11 isoform X1

Conserved Domains (1) summary

pfam11875
Location:131 → 270

DUF3395; Domain of unknown function (DUF3395)