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    Bcl2l13 BCL2 like 13 [ Mus musculus (house mouse) ]

    Gene ID: 94044, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Bcl2l13provided by MGI
    Official Full Name
    BCL2 like 13provided by MGI
    Primary source
    MGI:MGI:2136959
    See related
    Ensembl:ENSMUSG00000009112 AllianceGenome:MGI:2136959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mil1; Mil-1; BCL-RAMBO; E430016C20Rik
    Summary
    Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Located in mitochondrion. Orthologous to human BCL2L13 (BCL2 like 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 9.6), subcutaneous fat pad adult (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcl2l13 in Genome Data Viewer
    Location:
    6 F1; 6 57.01 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120813167..120869803)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120836206..120892842)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit E1 Neighboring gene STARR-positive B cell enhancer ABC_E1709 Neighboring gene STARR-positive B cell enhancer ABC_E6479 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 38889 Neighboring gene STARR-seq mESC enhancer starr_17194 Neighboring gene STARR-positive B cell enhancer ABC_E8126 Neighboring gene STARR-positive B cell enhancer ABC_E10407 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120880485-120880722 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120884294-120884494 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120885601-120885784 Neighboring gene STARR-positive B cell enhancer ABC_E6480 Neighboring gene BH3 interacting domain death agonist Neighboring gene STARR-positive B cell enhancer ABC_E11335 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120907410-120907630 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 3 Neighboring gene predicted gene, 43915

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A role for BCL2L13 and autophagy in germline purifying selection of mtDNA. Kremer LS, et al. PLoS Genet, 2023 Jan. PMID 36608143, Free PMC Article
    2. The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice. Fujiwara M, et al. J Biol Chem, 2019 Aug 23. PMID 31266807, Free PMC Article
    3. A novel role for Bcl2l13 in promoting beige adipocyte biogenesis. Ju L, et al. Biochem Biophys Res Commun, 2018 Nov 30. PMID 30352689
    4. By targeting apoptosis facilitator BCL2L13, microRNA miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice. Liu X, et al. Bioengineered, 2021 Dec. PMID 33724167, Free PMC Article
    5. MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. Schouten M, et al. Sci Rep, 2015 Jul 24. PMID 26207921, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.
      Title: A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.
    2. By targeting apoptosis facilitator BCL2L13, microRNA miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice.
      Title: By targeting apoptosis facilitator BCL2L13, microRNA miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice.
    3. The mitochondrial receptor Bcl2l13 promotes adipogenesis by increasing oxidative phosphorylation, suppressing apoptosis, and providing mitochondrial quality control through mitophagy.
      Title: The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice.
    4. Bcl2l13 disruption dramatically inhibited the browning program of preadipocytes, evidenced by reduced Prdm16, Ucp1, Dio2 and Adrb3 expression.
      Title: A novel role for Bcl2l13 in promoting beige adipocyte biogenesis.
    5. MicroRNA-124 and microRNA-137 cooperatively control caspase-3 activity through BCL2L13 in hippocampal neural stem cells.
      Title: MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38758

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    bcl-2-like protein 13
    Names
    BCL2-like 13 (apoptosis facilitator)
    bcl2-L-13
    mitochondria located 1 homolog
    protein Mil1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153516.2 → NP_705736.1  bcl-2-like protein 13

      See identical proteins and their annotated locations for NP_705736.1

      Status: VALIDATED

      Source sequence(s)
      AC083894, BC029016
      Consensus CDS
      CCDS20485.1
      UniProtKB/Swiss-Prot
      P59017, Q543S1
      UniProtKB/TrEMBL
      Q3UGC5
      Related
      ENSMUSP00000009256.3, ENSMUST00000009256.4
      Conserved Domains (1) summary
      pfam00452
      Location:101 → 197
      Bcl-2; Apoptosis regulator proteins, Bcl-2 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      120813167..120869803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506814.3 → XP_006506877.1  bcl-2-like protein 13 isoform X1

      UniProtKB/TrEMBL
      Q3UGC5
      Conserved Domains (2) summary
      pfam00452
      Location:67 → 163
      Bcl-2; Apoptosis regulator proteins, Bcl-2 family
      pfam17061
      Location:194 → 317
      PARM

    2. XM_017321842.2 → XP_017177331.1  bcl-2-like protein 13 isoform X2

      UniProtKB/TrEMBL
      Q3UGC5
      Conserved Domains (1) summary
      pfam00452
      Location:65 → 161
      Bcl-2; Apoptosis regulator proteins, Bcl-2 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59017.2 GenPept UniProtKB/Swiss-Prot:P59017

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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