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    Pals2 protein associated with LIN7 2, MAGUK family member [ Mus musculus (house mouse) ]

    Gene ID: 56524, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pals2provided by MGI
    Official Full Name
    protein associated with LIN7 2, MAGUK family memberprovided by MGI
    Primary source
    MGI:MGI:1927340
    See related
    Ensembl:ENSMUSG00000038388 AllianceGenome:MGI:1927340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mpp6; P55t
    Summary
    Predicted to enable guanylate kinase activity. Located in plasma membrane. Is expressed in heart. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 14.9), CNS E11.5 (RPKM 12.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B2.3; 6 24.13 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (50087206..50176134)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (50110228..50199154)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15836 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15837 Neighboring gene STARR-seq mESC enhancer starr_15840 Neighboring gene STARR-seq mESC enhancer starr_15842 Neighboring gene predicted gene, 38805 Neighboring gene STARR-seq mESC enhancer starr_15843 Neighboring gene gasdermin E Neighboring gene STARR-positive B cell enhancer mm9_chr6:50244177-50244478 Neighboring gene STARR-seq mESC enhancer starr_15846 Neighboring gene STARR-positive B cell enhancer ABC_E8102 Neighboring gene STARR-seq mESC enhancer starr_15847 Neighboring gene oxysterol binding protein-like 3 Neighboring gene predicted gene, 52900 Neighboring gene predicted gene, 40372

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system. Saitoh Y, et al. Histochem Cell Biol, 2019 May. PMID 30357511
    2. Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine. Kamijo A, et al. Histochem Cell Biol, 2016 Jan. PMID 26496923
    3. Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS. Terada N, et al. Histochem Cell Biol, 2013 Aug. PMID 23306908
    4. Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves. Terada N, et al. Mol Cell Biol, 2012 Jan. PMID 22025680, Free PMC Article
    5. Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells. Van Laer L, et al. Neurobiol Dis, 2005 Aug. PMID 16023581

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that the MPP6-Lin7 complex regulates myelin formation.
      Title: The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system.
    2. This paper herein showed the immunolocalization and interaction proteins of MPP6 in the mouse small intestine, and also that 4.1B in epithelial cells was not essential for the sorting of MPP6.
      Title: Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine.
    3. The findings indicate that the Src-MPP6-4.1G protein complex in Schmidt-Lanterman incisures(SLIs) has a role in signal transduction in the peripheral nervous system(PNS).
      Title: Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS.
    4. In the mouse sciatic nerve, protein 4.1G colocalized at Schmidt-Lanterman incisures (SLI) and the paranodes with a member of the membrane-associated guanylate kinase (MAGUK) family, membrane protein palmitoylated 6.
      Title: Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanylate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein PALS2
    Names
    MAGUK p55 subfamily member 6
    dlgh4 protein
    fibroblast growth factor-inducible protein 15
    membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 6)
    membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
    protein associated with Lin-7 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164733.2 → NP_001158205.1  protein PALS2 isoform a

      See identical proteins and their annotated locations for NP_001158205.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5-7 all encode isoform a.
      Source sequence(s)
      AC153618
      Consensus CDS
      CCDS51770.1
      UniProtKB/Swiss-Prot
      Q9JLB0, Q9JLB1, Q9WV37
      UniProtKB/TrEMBL
      Q3UN60
      Related
      ENSMUSP00000038772.9, ENSMUST00000036225.15
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:232 → 292
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:350 → 540
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    2. NM_001164734.2 → NP_001158206.1  protein PALS2 isoform a

      See identical proteins and their annotated locations for NP_001158206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 5-7 all encode isoform a.
      Source sequence(s)
      AC153618
      Consensus CDS
      CCDS51770.1
      UniProtKB/Swiss-Prot
      Q9JLB0, Q9JLB1, Q9WV37
      UniProtKB/TrEMBL
      Q3UN60
      Related
      ENSMUSP00000125880.2, ENSMUST00000166318.8
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:232 → 292
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:350 → 540
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    3. NM_001361247.2 → NP_001348176.1  protein PALS2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153618
      Consensus CDS
      CCDS20128.1
      UniProtKB/TrEMBL
      B9EHZ5
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:218 → 278
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:336 → 526
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    4. NM_001361248.2 → NP_001348177.1  protein PALS2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC153618
      Consensus CDS
      CCDS51770.1
      UniProtKB/Swiss-Prot
      Q9JLB0, Q9JLB1, Q9WV37
      UniProtKB/TrEMBL
      Q3UN60
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:232 → 292
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:350 → 540
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    5. NM_001411352.1 → NP_001398281.1  protein PALS2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC153618
      UniProtKB/Swiss-Prot
      Q9JLB0, Q9JLB1, Q9WV37
      UniProtKB/TrEMBL
      Q3UN60

    6. NM_001411353.1 → NP_001398282.1  protein PALS2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC153618
      UniProtKB/Swiss-Prot
      Q9JLB0, Q9JLB1, Q9WV37
      UniProtKB/TrEMBL
      Q3UN60

    7. NM_001411356.1 → NP_001398285.1  protein PALS2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153618
      UniProtKB/TrEMBL
      B9EHZ5
      Related
      ENSMUSP00000144737.2, ENSMUST00000204545.3

    8. NM_001411358.1 → NP_001398287.1  protein PALS2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153618
      UniProtKB/TrEMBL
      B9EHZ5

    9. NM_001411359.1 → NP_001398288.1  protein PALS2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153618
      UniProtKB/TrEMBL
      B9EHZ5

    10. NM_001411360.1 → NP_001398289.1  protein PALS2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153618
      UniProtKB/TrEMBL
      B9EHZ5

    11. NM_001411362.1 → NP_001398291.1  protein PALS2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC153618

    12. NM_001411366.1 → NP_001398295.1  protein PALS2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC153618

    13. NM_001411367.1 → NP_001398296.1  protein PALS2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC153618

    14. NM_019939.3 → NP_064323.2  protein PALS2 isoform b

      See identical proteins and their annotated locations for NP_064323.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8-11 all encode isoform b.
      Source sequence(s)
      AC153618
      Consensus CDS
      CCDS20128.1
      UniProtKB/TrEMBL
      B9EHZ5
      Related
      ENSMUSP00000039314.9, ENSMUST00000036236.15
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:218 → 278
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:336 → 526
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      50087206..50176134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255518.2 → XP_030111378.1  protein PALS2 isoform X3

      Conserved Domains (4) summary
      cd12038
      Location:207 → 267
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:107 → 180
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:325 → 515
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:32 → 83
      L27; L27 domain

    2. XM_036152240.1 → XP_036008133.1  protein PALS2 isoform X1

      UniProtKB/Swiss-Prot
      Q9JLB0, Q9JLB1, Q9WV37
      UniProtKB/TrEMBL
      Q3UN60
      Conserved Domains (5) summary
      smart00569
      Location:2 → 55
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12038
      Location:232 → 292
      SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
      cd00992
      Location:132 → 205
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:350 → 540
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:57 → 108
      L27; L27 domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_008016.2: Suppressed sequence

      Description
      NM_008016.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLB0.1 GenPept UniProtKB/Swiss-Prot:Q9JLB0

    Gene LinkOut

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