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    Saa2 serum amyloid A 2 [ Mus musculus (house mouse) ]

    Gene ID: 20209, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Saa2provided by MGI
    Official Full Name
    serum amyloid A 2provided by MGI
    Primary source
    MGI:MGI:98222
    See related
    Ensembl:ENSMUSG00000057465 AllianceGenome:MGI:98222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Saa1; Saa-2
    Summary
    Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within response to stilbenoid. Predicted to be located in cytoplasmic microtubule. Predicted to be part of high-density lipoprotein particle. Is expressed in liver. Orthologous to human SAA1 (serum amyloid A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 13.9), large intestine adult (RPKM 8.3) and 1 other tissue See more
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    Genomic context

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    Location:
    7 B3; 7 30.56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46401257..46403737)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46751833..46754313)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serum amyloid A, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18868 Neighboring gene serum amyloid A 1 Neighboring gene STARR-seq mESC enhancer starr_18870 Neighboring gene HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E6548 Neighboring gene STARR-seq mESC enhancer starr_18871 Neighboring gene general transcription factor II H, polypeptide 1 Neighboring gene Rap1A-retro1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pathogenetic mechanisms of amyloid A amyloidosis. Simons JP, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 23959890, Free PMC Article
    2. Influence of the carboxy terminus of serum amyloid A on protein oligomerization, misfolding, and fibril formation. Patke S, et al. Biochemistry, 2012 Apr 10. PMID 22448726, Free PMC Article
    3. Inflammation protein SAA2.2 spontaneously forms marginally stable amyloid fibrils at physiological temperature. Ye Z, et al. Biochemistry, 2011 Nov 1. PMID 21942925, Free PMC Article
    4. Serum amyloid A 2.2 refolds into a octameric oligomer that slowly converts to a more stable hexamer. Wang Y, et al. Biochem Biophys Res Commun, 2011 Apr 22. PMID 21439938, Free PMC Article
    5. Effect of zinc, copper, and calcium on the structure and stability of serum amyloid A. Wang L, et al. Biochemistry, 2007 May 8. PMID 17425332

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-kappaB signaling pathway.
      Title: FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-κB signaling pathway.
    2. Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN.
      Title: Acute aerobic exercise regulation of myocardial calcium homeostasis involves CASQ1, CASQ2, and TRDN.
    3. Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.
      Title: Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.
    4. SAA1/2 produced by macrophages promotes early lesion formation in the ascending aorta in LDLR knockout mice.
      Title: Serum Amyloid A Facilitates Early Lesion Development in Ldlr-/- Mice.
    5. CE/J mice possess functional Saa1 and Saa2 genes with identical amino acid sequence.
      Title: AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform.
    6. Its gene hold broader diversity and greater complexity and these characteristics were likely attained through gene duplication and repeated gene conversion events in the Mus lineage.
      Title: Diversity and complexity of the mouse Saa1 and Saa2 genes.
    7. The absence of endogenous SAA1.1 and 2.1 does not affect atherosclerotic lipid deposition in apolipoprotein E-deficient mice fed either normal or Western diets.
      Title: Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice.
    8. High level SAA expression induced amyloidosis in all mice after a short, slightly variable delay.
      Title: Pathogenetic mechanisms of amyloid A amyloidosis.
    9. Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2
      Title: Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2.
    10. These results suggest that the carboxy terminus of SAA, which is highly conserved among SAA sequences in all vertebrates, might play important structural roles, including modulating the folding, oligomerization, misfolding, and fibrillation of SAA.(Saa2)
      Title: Influence of the carboxy terminus of serum amyloid A on protein oligomerization, misfolding, and fibril formation.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stilbenoid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serum amyloid A-2 protein
    Names
    serum amyloid A 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357491.2 → NP_001344420.1  serum amyloid A-2 protein preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC090122
      Consensus CDS
      CCDS21285.1
      UniProtKB/Swiss-Prot
      P05367
      UniProtKB/TrEMBL
      P97375
      Related
      ENSMUSP00000075365.3, ENSMUST00000075982.4
      Conserved Domains (1) summary
      smart00197
      Location:21 → 122
      SAA; Serum amyloid A proteins

    2. NM_001379268.1 → NP_001366197.1  serum amyloid A-2 protein preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AC090122
      UniProtKB/Swiss-Prot
      P05367
      UniProtKB/TrEMBL
      P97375
      Conserved Domains (1) summary
      smart00197
      Location:21 → 122
      SAA; Serum amyloid A proteins

    3. NM_001379269.1 → NP_001366198.1  serum amyloid A-2 protein preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC090122
      UniProtKB/Swiss-Prot
      P05367
      UniProtKB/TrEMBL
      P97375
      Conserved Domains (1) summary
      smart00197
      Location:21 → 122
      SAA; Serum amyloid A proteins

    4. NM_011314.3 → NP_035444.1  serum amyloid A-2 protein preproprotein

      See identical proteins and their annotated locations for NP_035444.1

      Status: VALIDATED

      Source sequence(s)
      AC090122
      Consensus CDS
      CCDS21285.1
      UniProtKB/Swiss-Prot
      P05367
      UniProtKB/TrEMBL
      P97375
      Related
      ENSMUSP00000147751.2, ENSMUST00000210769.2
      Conserved Domains (1) summary
      smart00197
      Location:21 → 122
      SAA; Serum amyloid A proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46401257..46403737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05367.1 GenPept UniProtKB/Swiss-Prot:P05367

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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