Medag mesenteric estrogen dependent adipogenesis [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Medagprovided by MGI
Official Full Name: mesenteric estrogen dependent adipogenesisprovided by MGI
Primary source: MGI:MGI:1917967
See related: Ensembl:ENSMUSG00000029659 AllianceGenome:MGI:1917967
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Awms3; Meda4; MEDA-4; mAWMS3; 6330406I15Rik
Summary: Involved in positive regulation of fat cell differentiation. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human MEDAG (mesenteric estrogen dependent adipogenesis). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 6.3), subcutaneous fat pad adult (RPKM 4.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 89.18 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (149335214..149355188)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (149367641..149431723)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study identifies Meda-4 as a novel adipogenic gene, capable of promoting differentiation of preadipocytes into adipocytes, increasing lipid content and glucose uptake in adipocytes; it might play an important role in adipose tissue expansion in normal and aberrant hormonal conditions and pathophysiological states
Title: Novel genes of visceral adiposity: identification of mouse and human mesenteric estrogen-dependent adipose (MEDA)-4 gene and its adipogenic function.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit169 (e-PCR), detects polymorphism
- UniSTS:116317

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mesenteric estrogen-dependent adipogenesis protein

Names: activated in W/Wv mouse stomach 3; mesenteric estrogen-dependent adipose 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356995.1 → NP_001343924.1 mesenteric estrogen-dependent adipogenesis protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC114420, AK161526, AK165529

Consensus CDS

CCDS90023.1

Related

ENSMUSP00000144535.2, ENSMUST00000201083.2
NM_027519.4 → NP_081795.1 mesenteric estrogen-dependent adipogenesis protein isoform 1

See identical proteins and their annotated locations for NP_081795.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AK047657, AK161526

Consensus CDS

CCDS19884.1

UniProtKB/Swiss-Prot

Q14BA6, Q8BFY2, Q8C9B3, Q8CHK6, Q8R0K5, Q9CU47

Related

ENSMUSP00000090798.6, ENSMUST00000093110.12

RNA

NR_151595.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC114420