Adora1 adenosine A1 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adora1provided by MGI
Official Full Name: adenosine A1 receptorprovided by MGI
Primary source: MGI:MGI:99401
See related: Ensembl:ENSMUSG00000042429 AllianceGenome:MGI:99401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ri; A1R; A1AR; AA1R; ARA1; A1-AR
Summary: Predicted to enable several functions, including G protein-coupled adenosine receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in regulation of sensory perception of pain. Acts upstream of or within several processes, including excitatory postsynaptic potential; negative regulation of long-term synaptic depression; and negative regulation of mucus secretion. Located in dendritic spine. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and heart. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 63.0), cerebellum adult (RPKM 30.8) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.15 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134126953..134163195, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134199215..134235457, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.
Title: Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation.
Adenosine receptor A1 enhanced mitochondrial biogenesis and exerted neuroprotection after cerebral ischemia through PGC-1alpha.
Title: Adenosine receptor A1 enhanced mitochondrial biogenesis and exerted neuroprotection after cerebral ischemia through PGC-1α.
Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment.
Title: Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment.
Functional interplay between adenosine A2A receptor and NMDA preconditioning in fear memory and glutamate uptake in the mice hippocampus.
Title: Functional interplay between adenosine A(2A) receptor and NMDA preconditioning in fear memory and glutamate uptake in the mice hippocampus.
A1 and A2A adenosine receptors play a protective role to reduce prevalence of autoimmunity following tissue damage.
Title: A(1) and A(2A) adenosine receptors play a protective role to reduce prevalence of autoimmunity following tissue damage.
Adenosine A1 receptor is dispensable for hepatocyte glucose metabolism and insulin sensitivity.
Title: Adenosine A(1) receptor is dispensable for hepatocyte glucose metabolism and insulin sensitivity.
Input-selective adenosine A1 receptor-mediated synaptic depression of excitatory transmission in dorsal striatum.
Title: Input-selective adenosine A(1) receptor-mediated synaptic depression of excitatory transmission in dorsal striatum.
Analgesic action of adenosine A1 receptor involves the dephosphorylation of glycine receptor alpha1(ins) subunit in spinal dorsal horn of mice.
Title: Analgesic action of adenosine A1 receptor involves the dephosphorylation of glycine receptor α1(ins) subunit in spinal dorsal horn of mice.
Adenosine A2A receptor and vascular response: role of soluble epoxide hydrolase, adenosine A1 receptor and angiotensin-II.
Title: Adenosine A(2A) receptor and vascular response: role of soluble epoxide hydrolase, adenosine A(1) receptor and angiotensin-II.
ADORA1 promotes nasopharyngeal carcinoma cell progression through regulation of PI3K/AKT/GSK-3beta/beta-catenin signaling.
Title: ADORA1 promotes nasopharyngeal carcinoma cell progression through regulation of PI3K/AKT/GSK-3β/β-catenin signaling.

Submit: New GeneRIF Correction See all GeneRIFs (142)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Markers

AI385643 (e-PCR)
- UniSTS:178466

BB176431 (e-PCR)
- UniSTS:185452

Adora1 (e-PCR), detects polymorphism
- UniSTS:256460

AI848715 (e-PCR)
- UniSTS:165102

UniSTS:141040 (e-PCR)
- UniSTS:141040

Adora1 (e-PCR), detects polymorphism
- UniSTS:141040

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled adenosine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled adenosine receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables G-protein beta/gamma-subunit complex binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables heterotrimeric G-protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables purine nucleoside binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in inhibition of non-skeletal tissue mineralization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of leukocyte migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of long-term synaptic depression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mucus secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of circadian sleep/wake cycle, non-REM sleep	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of leukocyte migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of long-term synaptic depression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mucus secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neurotrophin production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nucleoside transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptide secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory gaseous exchange by nervous system process	ISO Inferred from Sequence Orthology more info
involved_in regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to inorganic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to inorganic substance	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to purine-containing compound	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine receptor A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008533.3 → NP_001008533.1 adenosine receptor A1 isoform a

See identical proteins and their annotated locations for NP_001008533.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC137104, AK045729, BY257408, DV552876

Consensus CDS

CCDS15305.1

UniProtKB/Swiss-Prot

Q60612, Q8BGU7, Q9WUF9

UniProtKB/TrEMBL

Q3UYG0, Q546D0, Q6AXD8, Q8CAH1

Related

ENSMUSP00000043522.7, ENSMUST00000038191.8

Conserved Domains (1) summary

cd15071
Location:10 → 299

7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001039510.2 → NP_001034599.1 adenosine receptor A1 isoform a

See identical proteins and their annotated locations for NP_001034599.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, and 3 encode the same protein (isoform a).

Source sequence(s)

AC137104, AK038774, AK134532, DV552876

Consensus CDS

CCDS15305.1

UniProtKB/Swiss-Prot

Q60612, Q8BGU7, Q9WUF9

UniProtKB/TrEMBL

Q3UYG0, Q546D0, Q6AXD8, Q8CAH1

Related

ENSMUSP00000083656.5, ENSMUST00000086465.6

Conserved Domains (1) summary

cd15071
Location:10 → 299

7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001282945.1 → NP_001269874.1 adenosine receptor A1 isoform a

See identical proteins and their annotated locations for NP_001269874.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1, 2, and 3 encode the same protein (isoform a).

Source sequence(s)

AC137104, AU080986, DV552876

Consensus CDS

CCDS15305.1

UniProtKB/Swiss-Prot

Q60612, Q8BGU7, Q9WUF9

UniProtKB/TrEMBL

Q3UYG0, Q546D0, Q6AXD8, Q8CAH1

Conserved Domains (1) summary

cd15071
Location:10 → 299

7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001291928.1 → NP_001278857.1 adenosine receptor A1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 2. The encoded protein (isoform b) has a distinct N-terminus and is shorter, compared to isoform a.

Source sequence(s)

AC137104, AK045729, BC079624, BY737264, DV552876

UniProtKB/Swiss-Prot

Q60612

UniProtKB/TrEMBL

Q6AXD8

Conserved Domains (1) summary

pfam00001
Location:23 → 198

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001291930.1 → NP_001278859.1 adenosine receptor A1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded protein (isoform c) is shorter, compared to isoform a.

Source sequence(s)

AK134532, AK134709, AK141531, BC058421, DV552876

UniProtKB/TrEMBL

S5RY33

Conserved Domains (1) summary

pfam00001
Location:58 → 146

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

134126953..134163195 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529079.4 → XP_006529142.1 adenosine receptor A1 isoform X1

See identical proteins and their annotated locations for XP_006529142.1

UniProtKB/Swiss-Prot

Q60612, Q8BGU7, Q9WUF9

UniProtKB/TrEMBL

Q3UYG0, Q546D0, Q6AXD8, Q8CAH1

Conserved Domains (1) summary

cd15071
Location:10 → 299

7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_009629.3: Suppressed sequence

Description

NM_009629.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.