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    Tgoln1 trans-golgi network protein [ Mus musculus (house mouse) ]

    Gene ID: 22134, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Tgoln1provided by MGI
    Official Full Name
    trans-golgi network proteinprovided by MGI
    Primary source
    MGI:MGI:105080
    See related
    Ensembl:ENSMUSG00000056429 AllianceGenome:MGI:105080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGN38; Ttgn1; TGN38A; D6Ertd384e
    Summary
    Located in endosome and trans-Golgi network. Is expressed in dorsal root ganglion. Orthologous to human TGOLN2 (trans-golgi network protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 72.1), kidney adult (RPKM 45.3) and 28 other tissues See more
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    Genomic context

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    Location:
    6 C1; 6 32.27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72585403..72593983, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72608420..72617000, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4833 Neighboring gene STARR-positive B cell enhancer ABC_E6443 Neighboring gene retinol saturase (all trans retinol 13,14 reductase) Neighboring gene transcription factor 7 like 1 (T cell specific, HMG box) Neighboring gene predicted gene 15401 Neighboring gene predicted gene, 31391 Neighboring gene 60S ribosomal protein L37 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TGN38 is required for the metaphase I/anaphase I transition and asymmetric cell division during mouse oocyte meiotic maturation. Chen L, et al. Cell Cycle, 2014. PMID 25486359, Free PMC Article
    2. Strain-specific presence of two TGN38 isoforms and absence of TGN41 in mouse. Kasai K, et al. J Biol Chem, 1995 Jun 16. PMID 7540170
    3. Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase. Steveson TC, et al. Endocrinology, 2003 Jan. PMID 12488345
    4. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Urushitani M, et al. Nat Neurosci, 2006 Jan. PMID 16369483
    5. LDL receptor related protein 1 requires the I(3) domain of discs-large homolog 1/DLG1 for interaction with the kinesin motor protein KIF13B. Mills J, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31487503, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TGN38 may regulate the metaphase I/anaphase I transition and asymmetric cell division in mouse oocytes.
      Title: TGN38 is required for the metaphase I/anaphase I transition and asymmetric cell division during mouse oocyte meiotic maturation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in trans-Golgi network transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    trans-Golgi network integral membrane protein 1
    Names
    trans-golgi network protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009443.3 → NP_033469.1  trans-Golgi network integral membrane protein 1 precursor

      See identical proteins and their annotated locations for NP_033469.1

      Status: VALIDATED

      Source sequence(s)
      AC125039, AK076586
      Consensus CDS
      CCDS51811.1
      UniProtKB/Swiss-Prot
      Q62313
      UniProtKB/TrEMBL
      Q3ULZ6, Q4FJY3
      Related
      ENSMUSP00000068487.5, ENSMUST00000070524.5
      Conserved Domains (1) summary
      PRK13108
      Location:99 → 285
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72585403..72593983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62313.1 GenPept UniProtKB/Swiss-Prot:Q62313

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