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    Abhd1 abhydrolase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 57742, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Abhd1provided by MGI
    Official Full Name
    abhydrolase domain containing 1provided by MGI
    Primary source
    MGI:MGI:1931013
    See related
    Ensembl:ENSMUSG00000006638 AllianceGenome:MGI:1931013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LABH1; LABH-1
    Summary
    Predicted to enable acetylesterase activity and acylglycerol lipase activity. Predicted to be involved in medium-chain fatty acid biosynthetic process and medium-chain fatty acid catabolic process. Is expressed in several structures, including clavicle; genitourinary system; liver; meninges; and thymus primordium. Orthologous to human ABHD1 (abhydrolase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Ubiquitous expression in small intestine adult (RPKM 30.2), duodenum adult (RPKM 28.3) and 28 other tissues See more
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    Genomic context

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    See Abhd1 in Genome Data Viewer
    Location:
    5 B1; 5 16.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31107410..31112439)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30950066..30955095)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4749 Neighboring gene ketohexokinase Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1679 Neighboring gene prolactin regulatory element binding Neighboring gene transcription factor 23 Neighboring gene STARR-seq mESC enhancer starr_12765 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E2741 Neighboring gene all-trans retinoic acid induced differentiation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alpha/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase. Stoelting M, et al. Biochem Biophys Res Commun, 2009 Jan 30. PMID 19073140
    2. Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs. Edgar AJ, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922611
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mRNA level of alpha/beta hydrolase 1 (ABHD1) is significantly upregulated in D5-/- mice.
      Title: Alpha/beta hydrolase 1 is upregulated in D5 dopamine receptor knockout mice and reduces O2- production of NADPH oxidase.
    2. LABH-1 protein is a member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the liver
      Title: Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in medium-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein ABHD1
    Names
    abhydrolase domain-containing protein 1
    alpha/beta hydrolase domain-containing protein 1
    alpha/beta hydrolase-1
    lung alpha/beta hydrolase 1
    mmLABH1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021304.3 → NP_067279.2  protein ABHD1

      See identical proteins and their annotated locations for NP_067279.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript expressed in NOD strain.
      Source sequence(s)
      BC013505
      UniProtKB/Swiss-Prot
      Q9QZC8
      Conserved Domains (2) summary
      pfam00561
      Location:131 → 372
      Abhydrolase_1; alpha/beta hydrolase fold
      cl21494
      Location:54 → 381
      Abhydrolase; alpha/beta hydrolases

    RNA

    1. NR_003522.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the transcript expressed in C57BL/6J.
      Source sequence(s)
      AA467032, AC109606, AK162873, CK789386, CK791402
      Related
      ENSMUST00000201125.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31107410..31112439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZC8.2 GenPept UniProtKB/Swiss-Prot:Q9QZC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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