Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agpat5provided by MGI
Official Full Name: 1-acylglycerol-3-phosphate O-acyltransferase 5provided by MGI
Primary source: MGI:MGI:1196345
See related: Ensembl:ENSMUSG00000031467 AllianceGenome:MGI:1196345
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D8Ertd319e; 1110013A05Rik
Summary: Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Acts upstream of or within acylglycerol metabolic process and hematopoietic progenitor cell differentiation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AGPAT5 (1-acylglycerol-3-phosphate O-acyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 12.3), placenta adult (RPKM 11.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.3; 8 10.3 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (18896295..18934429)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (18846279..18884413)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Ertd319e (e-PCR), detects polymorphism
- UniSTS:167561

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acylglycerol metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Names: 1-AGP acyltransferase 5; 1-AGPAT 5; 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon); LPAAT-epsilon; lysophosphatidic acid acyltransferase epsilon

NP_081068.1

EC 2.3.1.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026792.3 → NP_081068.1 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

See identical proteins and their annotated locations for NP_081068.1

Status: VALIDATED

Source sequence(s)

AC129567, BC062903

Consensus CDS

CCDS22126.1

UniProtKB/Swiss-Prot

Q3U702, Q8BG61, Q8CGN6, Q9D1E8

UniProtKB/TrEMBL

Q3TDP3

Related

ENSMUSP00000117025.2, ENSMUST00000149565.8

Conserved Domains (2) summary

cd07990
Location:63 → 264

LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like

pfam16076
Location:260 → 319

Acyltransf_C; Acyltransferase C-terminus