Fpr1 formyl peptide receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fpr1provided by MGI
Official Full Name: formyl peptide receptor 1provided by MGI
Primary source: MGI:MGI:107443
See related: Ensembl:ENSMUSG00000045551 AllianceGenome:MGI:107443
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FPR; LXA4R; fMLF-R
Summary: Enables N-formyl peptide receptor activity. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in ductus deferens; epididymis; ileum; prostate gland; and testis. Orthologous to human FPR1 (formyl peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 10.0), lung adult (RPKM 7.0) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.2; 17 10.63 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (18096733..18104201, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (17876471..17883939, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of formyl peptide receptor 1 reduces osteogenesis and bone healing.
Title: Knockout of formyl peptide receptor 1 reduces osteogenesis and bone healing.
Formylpeptide receptor 1 contributes to epidermal barrier dysfunction-induced skin inflammation through NOD-like receptor C4-dependent keratinocyte activation.
Title: Formylpeptide receptor 1 contributes to epidermal barrier dysfunction-induced skin inflammation through NOD-like receptor C4-dependent keratinocyte activation.
Formyl peptide receptor 1 is involved in surgery-induced neuroinflammation and dysfunction of learning and memory in mice.
Title: Formyl peptide receptor 1 is involved in surgery-induced neuroinflammation and dysfunction of learning and memory in mice.
Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis.
Title: Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis.
Critical role of FPR1 in splenocyte migration into brain to worsen inflammation and ischemic brain injury in mice.
Title: Critical role of FPR1 in splenocyte migration into brain to worsen inflammation and ischemic brain injury in mice.
Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound.
Title: Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound.
Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways.
Title: Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways.
Downregulation of FPR1 abates lipopolysaccharide-induced inflammatory injury and apoptosis by upregulating MAPK signaling pathway in murine chondrogenic ATDC5 cells.
Title: Downregulation of FPR1 abates lipopolysaccharide-induced inflammatory injury and apoptosis by upregulating MAPK signaling pathway in murine chondrogenic ATDC5 cells.
Leukocyte chemotactic receptor Fpr1 protects against aging-related posterior subcapsular cataract formation.
Title: Leukocyte chemotactic receptor Fpr1 protects against aging-related posterior subcapsular cataract formation.
Modulation of NLRP3 Inflammasome through Formyl Peptide Receptor 1 (Fpr-1) Pathway as a New Therapeutic Target in Bronchiolitis Obliterans Syndrome.
Title: Modulation of NLRP3 Inflammasome through Formyl Peptide Receptor 1 (Fpr-1) Pathway as a New Therapeutic Target in Bronchiolitis Obliterans Syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:546772

Fpr1 (e-PCR), detects polymorphism
- UniSTS:546772

NoName (e-PCR)
- UniSTS:489187

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables N-formyl peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-formyl peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables N-formyl peptide receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables RAGE receptor binding	ISO Inferred from Sequence Orthology more info
enables complement receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables scavenger receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fMet-Leu-Phe receptor

Names: N-formyl peptide receptor; N-formylpeptide chemoattractant receptor; fMLP receptor; lipoxin A4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.