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    Son Son DNA binding protein [ Mus musculus (house mouse) ]

    Gene ID: 20658, updated on 17-Mar-2024

    Summary

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    Official Symbol
    Sonprovided by MGI
    Official Full Name
    Son DNA binding proteinprovided by MGI
    Primary source
    MGI:MGI:98353
    See related
    Ensembl:ENSMUSG00000022961 AllianceGenome:MGI:98353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nrebp; mKIAA1019; 2900011L12Rik
    Summary
    Enables RS domain binding activity. Predicted to be involved in several processes, including mRNA processing; mitotic cytokinesis; and regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing. Predicted to be located in nuclear speck. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SON (SON DNA and RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 48.2), ovary adult (RPKM 44.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C3.3- C4; 16 53.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91444712..91476080)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91647824..91679192)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:91619128-91619428 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene phosphoribosylglycinamide formyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E3174 Neighboring gene STARR-positive B cell enhancer ABC_E7475 Neighboring gene predicted gene, 36712 Neighboring gene downstream neighbor of SON Neighboring gene STARR-positive B cell enhancer ABC_E2468 Neighboring gene predicted gene 10785 Neighboring gene crystallin zeta like 1 Neighboring gene predicted gene, 46543

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities. Ueda M, et al. Mol Brain, 2020 May 24. PMID 32448361, Free PMC Article
    2. Conserved gene sequences for species identification: PCR analysis of the 3' UTR of the SON gene distinguishes human and other mammalian DNAs. Soteriou B, et al. Forensic Sci Int, 1995 Jun 21. PMID 7657183
    3. Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons. Komori T, et al. J Biol Chem, 2010 Nov 26. PMID 20876580, Free PMC Article
    4. Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes. Wynn SL, et al. Genomics, 2000 Aug 15. PMID 10950926
    5. Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis. Ahn EY, et al. Proc Natl Acad Sci U S A, 2008 Nov 4. PMID 18952841, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis.
      Title: A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis.
    2. SON is an essential m[6]A target for hematopoietic stem cell fate.
      Title: SON is an essential m(6)A target for hematopoietic stem cell fate.
    3. Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.
      Title: Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.
    4. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster
      Title: SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.
    5. Leptin-induced NREBP is an important regulator of ghrelin signaling in the hypothalamus.
      Title: Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RS domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein SON
    Names
    NRE-binding protein
    Son cell proliferation protein
    negative regulatory element-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019973.2 → NP_064357.2  protein SON isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC131691, AK040621, BC061113, BG229132, CJ088081
      Consensus CDS
      CCDS37400.1
      UniProtKB/TrEMBL
      H9KV01
      Related
      ENSMUSP00000109670.3, ENSMUST00000114036.9
      Conserved Domains (1) summary
      pfam08430
      Location:1011 → 1137
      Forkhead_N; Forkhead N-terminal region

    2. NM_178880.4 → NP_849211.3  protein SON isoform 1

      See identical proteins and their annotated locations for NP_849211.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131691, AK040621, AK122418, BC061113, CB849818, CJ088081
      Consensus CDS
      CCDS37399.1
      UniProtKB/Swiss-Prot
      E3WC91, E9PXW2, E9Q3H8, E9Q3I0, E9Q6M4, E9Q7G2, E9QAR8, E9QMT0, Q811G3, Q9CQ12, Q9CQK6, Q9QX47, Q9QXP5
      UniProtKB/TrEMBL
      H9KV00
      Related
      ENSMUSP00000109671.3, ENSMUST00000114037.9
      Conserved Domains (3) summary
      cd00048
      Location:2389 → 2426
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam08430
      Location:1011 → 1137
      Forkhead_N; Forkhead N-terminal region
      pfam01585
      Location:2323 → 2366
      G-patch; G-patch domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91444712..91476080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QX47.2 GenPept UniProtKB/Swiss-Prot:Q9QX47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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