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    Atraid all-trans retinoic acid induced differentiation factor [ Mus musculus (house mouse) ]

    Gene ID: 381629, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Atraidprovided by MGI
    Official Full Name
    all-trans retinoic acid induced differentiation factorprovided by MGI
    Primary source
    MGI:MGI:1918918
    See related
    Ensembl:ENSMUSG00000013622 AllianceGenome:MGI:1918918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p18; Apr3; HSPC013; 0610007C21Rik
    Summary
    Predicted to be involved in several processes, including negative regulation of osteoblast proliferation; positive regulation of bone mineralization; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within cell differentiation. Located in lysosomal membrane. Orthologous to human ATRAID (all-trans retinoic acid induced differentiation factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 98.8), genital fat pad adult (RPKM 68.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atraid in Genome Data Viewer
    Location:
    5 B1; 5 16.94 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31205984..31211977)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31048640..31054633)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding Neighboring gene transcription factor 23 Neighboring gene STARR-seq mESC enhancer starr_12765 Neighboring gene STARR-positive B cell enhancer ABC_E2741 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene predicted gene, 38601 Neighboring gene solute carrier family 30 (zinc transporter), member 3 Neighboring gene predicted gene 9924

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATRAID regulates the action of nitrogen-containing bisphosphonates on bone. Surface LE, et al. Sci Transl Med, 2020 May 20. PMID 32434850, Free PMC Article
    2. Apoptosis related protein 3 is a lysosomal membrane protein. Ding X, et al. Biochem Biophys Res Commun, 2015 May 15. PMID 25839652
    3. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Yu Z, et al. Elife, 2018 May 10. PMID 29745899, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of osteoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    all-trans retinoic acid-induced differentiation factor
    Names
    H1E6 protein
    apoptosis related protein APR-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027855.4 → NP_082131.2  all-trans retinoic acid-induced differentiation factor isoform 1 precursor

      See identical proteins and their annotated locations for NP_082131.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AW987473, BC057097, BY033481
      Consensus CDS
      CCDS19170.1
      UniProtKB/Swiss-Prot
      Q3UAH4, Q6PGD0, Q810Q3, Q9DD14
      UniProtKB/TrEMBL
      A8C1S6
      Related
      ENSMUSP00000013766.7, ENSMUST00000013766.13

    2. NM_212470.3 → NP_997635.1  all-trans retinoic acid-induced differentiation factor isoform 2

      See identical proteins and their annotated locations for NP_997635.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK169267, AW987473, BY033481
      UniProtKB/TrEMBL
      D3Z6U7
      Related
      ENSMUSP00000144085.2, ENSMUST00000201136.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31205984..31211977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PGD0.2 GenPept UniProtKB/Swiss-Prot:Q6PGD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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