Srsf10 serine and arginine-rich splicing factor 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srsf10provided by MGI
Official Full Name: serine and arginine-rich splicing factor 10provided by MGI
Primary source: MGI:MGI:1333805
See related: Ensembl:ENSMUSG00000028676 AllianceGenome:MGI:1333805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nssr; TASR; NSSR1; NSSR2; TASR1; TASR2; FUSIP2; Fusip1; SRrp40; Sfrs13a; Srsf13a
Summary: Predicted to enable RNA binding activity. Involved in RNA splicing, via transesterification reactions; cytosolic transport; and negative regulation of mRNA splicing, via spliceosome. Located in nucleoplasm. Is expressed in several structures, including brain; branchial arch; foregut-midgut junction; heart ventricle; and sensory organ. Orthologous to human SRSF10 (serine and arginine rich splicing factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 24.5), limb E14.5 (RPKM 19.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 68.01 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135582454..135597219)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (135855752..135869908)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing.
Title: SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing.
Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease.
Title: Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease.
Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.
Title: Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.
SRSF10 represses inclusion of PGC1alpha exon 7a.
Title: SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing.
The results of this study suggested for the first time that NSSR1 may provide a novel mechanism for reducing neuronal injury after ischemia, probably through regulation on alternative splicing of NCAM-L1 and CREB in astrocytes.
Title: Splicing factor NSSR1 reduces neuronal injury after mouse transient global cerebral ischemia.
We further show that an SRSRSK sequence in the RS3 domain may play an important role in the function of NSSR1 in pre-mRNA splicing.
Title: Dephosphorylation of NSSR1 regulates alternative splicing of the GluR-B minigene.
These results identify SRSF10 as an essential regulator for adipocyte differentiation.
Title: SRSF10 regulates alternative splicing and is required for adipocyte differentiation.
the potential roles of NSSR1 in sperm maturation and fertilization
Title: Dephosphorylated NSSR1 is induced by androgen in mouse epididymis and phosphorylated NSSR1 is increased during sperm maturation.
NSSR1 mRNA was expressed in mouse cerebrum, cerebellum, heart, liver, intestine, kidney and lung tissue, but NSSR1 protein was only expressed in neural tissues.
Title: [Expression of neural salient serine-/arginine-rich protein 1 (NSSR1) in colorectal cancer].
SRp38 regulates cardiac-specific alternative splicing of triadin pre-mRNA and, reflecting this, is essential for proper Ca(2+) handling during embryonic heart development.
Title: SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fusip1 (e-PCR), detects polymorphism
- UniSTS:525486

UniSTS:479158 (e-PCR)
- UniSTS:479158

Fusip1 (e-PCR), detects polymorphism
- UniSTS:479158

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing, via transesterification reactions	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA splicing, via transesterification reactions	ISO Inferred from Sequence Orthology more info
involved_in cytosolic transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splice site recognition	IC Inferred by Curator more info	PubMed
involved_in mRNA splice site recognition	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 10

Names: FUS-interacting serine-arginine-rich protein 1; Fus-associated protein with serine-arginine repeats; TLS-associated SR protein; TLS-associated protein with SR repeats; TLS-associated protein with Ser-Arg repeats; TLS-associated serine-arginine protein; neural-salient serine/arginine-rich protein; neural-specific SR protein; serine/arginine-rich splicing factor 13A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080387.2 → NP_001073856.1 serine/arginine-rich splicing factor 10 isoform 2

See identical proteins and their annotated locations for NP_001073856.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2).

Source sequence(s)

AK168558, BC043060, BY244789, BY717856

Consensus CDS

CCDS38922.1

UniProtKB/Swiss-Prot

B1AV44, B1AV45, O70307, O88468, Q3TGW7, Q8CFZ1, Q9R0T9, Q9R0U0

UniProtKB/TrEMBL

Q3UXS8

Related

ENSMUSP00000101479.4, ENSMUST00000105853.10

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001284195.1 → NP_001271124.1 serine/arginine-rich splicing factor 10 isoform 3

See identical proteins and their annotated locations for NP_001271124.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.

Source sequence(s)

AK168524, BC043060, BY244789, BY717856, CF914989, CN528501

Consensus CDS

CCDS71493.1

UniProtKB/TrEMBL

Q3UXS8

Related

ENSMUSP00000095455.3, ENSMUST00000097844.9

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001284196.1 → NP_001271125.1 serine/arginine-rich splicing factor 10 isoform 4

See identical proteins and their annotated locations for NP_001271125.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and contains an alternate 3' terminal exon, compared to variant 2. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AF042383, AK030968, AK168571, AK169071, BY244789, BY717856

Consensus CDS

CCDS71494.1

UniProtKB/TrEMBL

Q3TFP0, Q3UDH7

Related

ENSMUSP00000099603.3, ENSMUST00000102544.9

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily
NM_010178.3 → NP_034308.1 serine/arginine-rich splicing factor 10 isoform 1

See identical proteins and their annotated locations for NP_034308.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) contains an alternate 3' terminal exon compared to variant 2. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

AF042383, AK030968, AK168558, AK168571, BY244789, BY717856

Consensus CDS

CCDS18791.1

UniProtKB/TrEMBL

Q3UA07, Q3UDH7

Related

ENSMUSP00000114564.2, ENSMUST00000126641.2

Conserved Domains (1) summary

cd12559
Location:5 → 99

RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

135582454..135597219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250188.3 → XP_011248490.1 serine/arginine-rich splicing factor 10 isoform X3

See identical proteins and their annotated locations for XP_011248490.1

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily
XM_036163676.1 → XP_036019569.1 serine/arginine-rich splicing factor 10 isoform X1

UniProtKB/TrEMBL

Q3UDH7

Conserved Domains (1) summary

cd12559
Location:5 → 99

RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins
XM_036163677.1 → XP_036019570.1 serine/arginine-rich splicing factor 10 isoform X2

Conserved Domains (1) summary

cl17169
Location:5 → 99

RRM_SF; RNA recognition motif (RRM) superfamily