Siah1b siah E3 ubiquitin protein ligase 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Siah1bprovided by MGI
Official Full Name: siah E3 ubiquitin protein ligase 1Bprovided by MGI
Primary source: MGI:MGI:108063
See related: Ensembl:ENSMUSG00000040749 AllianceGenome:MGI:108063
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sinh1b; siah-1b
Summary: This gene encodes a member of the seven in absentia homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze the transfer of ubiquitin to substrate proteins. The encoded protein targets Pard3A (partitioning defective 3A) protein for proteasome-mediated degradation during the exit of cerebellar granule neurons from their germinal zone niche. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 7.7), liver E14.5 (RPKM 6.2) and 28 other tissues See more
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Genomic context

Location:: X F5; X 76.11 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (162853699..162859489, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (164070703..164076493, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings define a Siah-Pard3A signaling pathway that controls adhesion-dependent exit of neuronal progenitors or immature neurons from a germinal zone niche
Title: Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.
Results from loss-of-function experiments do not support a general role for Siah genes in p53-mediated responses or mitosis.
Title: Normal p53 function in primary cells deficient for Siah genes.
Siah1 is a binding partner for POSH (plenty of SH3s), a scaffold component of the apoptotic JNK pathway
Title: Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Siah1b (e-PCR), detects polymorphism
- UniSTS:144404

Siah1b (e-PCR), detects polymorphism
- UniSTS:507224

AA960570 (e-PCR)
- UniSTS:160905

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of beta-catenin destruction complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase SIAH1B

Names: RING-type E3 ubiquitin transferase SIAH1B; drosophila seven-in-absentia gene product homolog; seven in absentia 1B; seven in absentia homolog 1b

NP_001295314.1

EC 2.3.2.27

NP_001295315.1

EC 2.3.2.27

NP_033199.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308385.1 → NP_001295314.1 E3 ubiquitin-protein ligase SIAH1B

See identical proteins and their annotated locations for NP_001295314.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AL732294, BC052887, CF723667, CJ094899, DV648408

Consensus CDS

CCDS30516.1

UniProtKB/Swiss-Prot

Q06985, Q7TPV6

UniProtKB/TrEMBL

A2AHZ2

Conserved Domains (1) summary

pfam03145
Location:82 → 278

Sina; Seven in absentia protein family
NM_001308386.1 → NP_001295315.1 E3 ubiquitin-protein ligase SIAH1B

See identical proteins and their annotated locations for NP_001295315.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AL732294, BC052887, DV648408

Consensus CDS

CCDS30516.1

UniProtKB/Swiss-Prot

Q06985, Q7TPV6

UniProtKB/TrEMBL

A2AHZ2

Related

ENSMUSP00000071592.3, ENSMUST00000071667.9

Conserved Domains (1) summary

pfam03145
Location:82 → 278

Sina; Seven in absentia protein family
NM_009173.2 → NP_033199.1 E3 ubiquitin-protein ligase SIAH1B

See identical proteins and their annotated locations for NP_033199.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AL732294, BC052887, CJ063158, DV648408

Consensus CDS

CCDS30516.1

UniProtKB/Swiss-Prot

Q06985, Q7TPV6

UniProtKB/TrEMBL

A2AHZ2

Related

ENSMUSP00000043215.3, ENSMUST00000037928.9

Conserved Domains (1) summary

pfam03145
Location:82 → 278

Sina; Seven in absentia protein family