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    Slc22a18 solute carrier family 22 (organic cation transporter), member 18 [ Mus musculus (house mouse) ]

    Gene ID: 18400, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Slc22a18provided by MGI
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 18provided by MGI
    Primary source
    MGI:MGI:1336884
    See related
    Ensembl:ENSMUSG00000000154 AllianceGenome:MGI:1336884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HET; ITM; BWR1A; Impt1; TSSC5; Orctl2; BWSCR1A; Slc22a1l; p45-BWR1A
    Summary
    Predicted to enable transmembrane transporter activity and ubiquitin protein ligase binding activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to act upstream of or within anion transport. Predicted to be located in apical plasma membrane; cytoplasm; and nuclear envelope. Predicted to be integral component of plasma membrane. Is expressed in several structures, including liver; metanephros; nervous system; placenta; and yolk sac. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SLC22A18 (solute carrier family 22 member 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 388.3), duodenum adult (RPKM 122.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F5; 7 88.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143027502..143053071)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143473726..143499334)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase inhibitor 1C Neighboring gene predicted gene, 33663 Neighboring gene pleckstrin homology like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene predicted gene, 23297

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired expression of an organic cation transporter, IMPT1, in a knockout mouse model for kidney stone disease. Tzortzaki EG, et al. Urol Res, 2003 Aug. PMID 12856169
    2. A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice. Morisaki H, et al. DNA Res, 1998 Aug 31. PMID 9802569
    3. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. Cooper PR, et al. Genomics, 1998 Apr 1. PMID 9570947
    4. IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. Dao D, et al. Hum Mol Genet, 1998 Apr. PMID 9499412
    5. Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome. Singh VB, et al. Development, 2017 May 15. PMID 28428215, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Slc22a18/Itm gene is imprinted, with preferential expression from the maternal allele in fetal, newborn and most adult tissues, but biallelic expression in adult kidney and liver.
      Title: A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.
    2. decreased IMPT1 mRNA expression may contribute to the impaired renal function in APRT-deficient male mice
      Title: Impaired expression of an organic cation transporter, IMPT1, in a knockout mouse model for kidney stone disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic anion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 22 member 18
    Names
    ORCTL-2
    imprinted multi-membrane spanning polyspecific transporter-related protein 1
    organic cationic transporter-like 2
    tumor suppressing subtransferable candidate 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042760.2 → NP_001036225.1  solute carrier family 22 member 18 isoform b

      See identical proteins and their annotated locations for NP_001036225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' non-coding exon; hence, differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (b).
      Source sequence(s)
      AB012084, BU758157
      Consensus CDS
      CCDS22041.1
      UniProtKB/Swiss-Prot
      O35428, O54959, O88283, Q78KK3, Q99NF4
      UniProtKB/TrEMBL
      A0A0R4J0P7
      Related
      ENSMUSP00000101537.3, ENSMUST00000105917.3
      Conserved Domains (2) summary
      cd06174
      Location:14 → 378
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:14 → 367
      MFS_1; Major Facilitator Superfamily

    2. NM_001417039.1 → NP_001403968.1  solute carrier family 22 member 18 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC023248

    3. NM_001417040.1 → NP_001403969.1  solute carrier family 22 member 18 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC023248

    4. NM_001417041.1 → NP_001403970.1  solute carrier family 22 member 18 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC023248

    5. NM_008767.3 → NP_032793.2  solute carrier family 22 member 18 isoform b

      See identical proteins and their annotated locations for NP_032793.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (b).
      Source sequence(s)
      AK002460, BB869719, BE865039, BU758157
      Consensus CDS
      CCDS22041.1
      UniProtKB/Swiss-Prot
      O35428, O54959, O88283, Q78KK3, Q99NF4
      UniProtKB/TrEMBL
      A0A0R4J0P7
      Related
      ENSMUSP00000056082.6, ENSMUST00000052348.12
      Conserved Domains (2) summary
      cd06174
      Location:14 → 378
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:14 → 367
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143027502..143053071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508514.4 → XP_006508577.1  solute carrier family 22 member 18 isoform X4

      UniProtKB/TrEMBL
      Q05DG8
      Conserved Domains (1) summary
      cl28910
      Location:1 → 271
      MFS; Major Facilitator Superfamily

    2. XM_006508513.3 → XP_006508576.1  solute carrier family 22 member 18 isoform X3

      UniProtKB/TrEMBL
      Q05DG8
      Conserved Domains (1) summary
      cl28910
      Location:1 → 279
      MFS; Major Facilitator Superfamily

    3. XM_006508511.3 → XP_006508574.1  solute carrier family 22 member 18 isoform X1

      See identical proteins and their annotated locations for XP_006508574.1

      UniProtKB/Swiss-Prot
      O35428, O54959, O88283, Q78KK3, Q99NF4
      Conserved Domains (1) summary
      cd17331
      Location:13 → 396
      MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters

    4. XM_006508512.3 → XP_006508575.1  solute carrier family 22 member 18 isoform X2

      UniProtKB/Swiss-Prot
      O35428, O54959, O88283, Q78KK3, Q99NF4
      Conserved Domains (1) summary
      cd17331
      Location:7 → 366
      MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78KK3.2 GenPept UniProtKB/Swiss-Prot:Q78KK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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