Usp11 ubiquitin specific peptidase 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp11provided by MGI
Official Full Name: ubiquitin specific peptidase 11provided by MGI
Primary source: MGI:MGI:2384312
See related: Ensembl:ENSMUSG00000031066 AllianceGenome:MGI:2384312
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4085; 6230415D12Rik
Summary: Predicted to enable thiol-dependent deubiquitinase and transcription corepressor binding activity. Predicted to be involved in protein deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human USP11 (ubiquitin specific peptidase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E14 (RPKM 22.1), whole brain E14.5 (RPKM 21.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.3; X 16.2 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (20570148..20586778)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (20703909..20720539)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP11 plays a critical role in the onset and progression of acute graft-versus-host diseaseNovel target for precision therapeutics.
Title: USP11 plays a critical role in the onset and progression of acute graft-versus-host disease：Novel target for precision therapeutics.
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-beta receptor II.
Title: Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II.
Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis.
Title: Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis.
USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1.
Title: USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1.
Targeting USP11 may alleviate radiation-induced pulmonary fibrosis by regulating endothelium tight junction.
Title: Targeting USP11 may alleviate radiation-induced pulmonary fibrosis by regulating endothelium tight junction.
USP11 specifically regulates TGF-beta signaling in CD4+ T cell subsets, probably through its role as a regulator of the ubiquitylation-mediated negative feedback loop that limits TGF-beta signals upon the activation of the pathway.
Title: The Deubiquitinating Enzyme Ubiquitin-Specific Peptidase 11 Potentiates TGF-β Signaling in CD4(+) T Cells to Facilitate Foxp3(+) Regulatory T and T(H)17 Cell Differentiation.
USP11 may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta-1 signaling.
Title: De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II.
USP11 augments TGFbeta signalling by deubiquitylating ALK5.
Title: USP11 augments TGFβ signalling by deubiquitylating ALK5.
structural and functional characterization of the USP11 deubiquitinating enzyme
Title: Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 11

Names: deubiquitinating enzyme 11; ubiquitin thioesterase 11; ubiquitin thiolesterase 11; ubiquitin-specific-processing protease 11

NP_001345860.1

EC 3.4.19.12

NP_663603.3

EC 3.4.19.12

XP_030107181.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358931.1 → NP_001345860.1 ubiquitin carboxyl-terminal hydrolase 11 isoform 2

Status: VALIDATED

Source sequence(s)

AL807240

UniProtKB/TrEMBL

Q8C0C2

Conserved Domains (1) summary

cl02553
Location:1 → 774

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
NM_145628.4 → NP_663603.3 ubiquitin carboxyl-terminal hydrolase 11 isoform 1

See identical proteins and their annotated locations for NP_663603.3

Status: VALIDATED

Source sequence(s)

AK031767, AK049053, AK169116, BY272535

Consensus CDS

CCDS53015.1

UniProtKB/Swiss-Prot

B1AXB2, Q3TLG5, Q99K46

Related

ENSMUSP00000033383.3, ENSMUST00000033383.3

Conserved Domains (6) summary

smart00695
Location:44 → 136

DUSP; Domain in ubiquitin-specific proteases

COG5560
Location:23 → 888

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd02674
Location:737 → 887

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:258 → 437

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam14533
Location:428 → 541

USP7_C2; Ubiquitin-specific protease C-terminal

pfam14836
Location:154 → 233

Ubiquitin_3; Ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

20570148..20586778

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251321.1 → XP_030107181.1 ubiquitin carboxyl-terminal hydrolase 11 isoform X1

UniProtKB/TrEMBL

Q8C0C2

Conserved Domains (1) summary

COG5560
Location:39 → 654

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]