Celf1 CUGBP, Elav-like family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Celf1provided by MGI
Official Full Name: CUGBP, Elav-like family member 1provided by MGI
Primary source: MGI:MGI:1342295
See related: Ensembl:ENSMUSG00000005506 AllianceGenome:MGI:1342295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CUGBP; NAB50; CUG-BP; Cugbp1; HNAB50; Brunol2; CUG-BP1; D2Wsu101e; 1600010O03Rik
Summary: Enables long noncoding RNA binding activity; mRNA 5'-UTR binding activity; and translation initiation factor binding activity. Acts upstream of or within several processes, including forebrain development; mRNA splice site selection; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; early embryo; musculature; nervous system; and testis. Orthologous to human CELF1 (CUGBP Elav-like family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 28.2), whole brain E14.5 (RPKM 28.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 50.44 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (90770604..90849842)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (90940259..91019497)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.
Title: High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology.
Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury.
Title: Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury.
Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting.
Title: Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting.
CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure.
Title: CELF1 promotes vascular endothelial growth factor degradation resulting in impaired microvasculature in heart failure.
The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.
Title: The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.
RNA-seq analysis of mouse neocortical polysomes demonstrated that the translation of distinct mRNA isoforms of the RNA binding protein (RBP), Elavl4, in radial glia progenitors and early neurons depends on its alternative 5' UTRs. 5' UTR-driven Elavl4 isoform-specific translation depends on upstream control by another RBP, Celf1. Celf1 regulation of Elavl4 translation dictates development of glutamatergic neurons.
Title: Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development.
miR-206 helped rescue myogenic deficiency by inhibiting CUGBP1 accumulation in cell models of myotonic dystrophy. These data suggest that increased miR-206 levels in myoblasts may lead to better skeletal muscle differentiation.
Title: Mir-206 partially rescues myogenesis deficiency by inhibiting CUGBP1 accumulation in the cell models of myotonic dystrophy.
These results indicate that CELF1 target RNAs are aberrantly spliced in the Type 1 diabetic heart leading to abnormal gene expression.
Title: CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart.
this study shows that the absence of Celf1 causes neonatal cardiac dysfunction and transcriptome changes
Title: Neonatal cardiac dysfunction and transcriptome changes caused by the absence of Celf1.
Results found that the blood level of CUGBP1 in mice was decreased during the progression of acute myocardial infarction (AMI) and demonstrate that CUGBP1 is functionally important in AMI. This finding reveals the roles of CUGBP1 in the heart not only during development but also in cardiac disease.
Title: Reconstitution of HuR-Inhibited CUGBP1 Expression Protects Cardiomyocytes from Acute Myocardial Infarction-Induced Injury.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Wsu101e (e-PCR), detects polymorphism
- UniSTS:142367

CUGBP1_2383 (e-PCR)
- UniSTS:280629

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Cugbp1 (e-PCR), detects polymorphism
- UniSTS:479088

X61451 (e-PCR)
- UniSTS:125827

RH125691 (e-PCR)
- UniSTS:162464

AU015122 (e-PCR)
- UniSTS:167339

NoName (e-PCR)
- UniSTS:234451

NoName (e-PCR)
- UniSTS:234453

NoName (e-PCR)
- UniSTS:234457

NoName (e-PCR)
- UniSTS:234458

MARC_7541-7542:996687927:1 (e-PCR)
- UniSTS:269790

MARC_11599-11600:1002739035:1 (e-PCR)
- UniSTS:267239

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BRE binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splice site recognition	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA splice site recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA splice site recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in perinucleolar compartment	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CUGBP Elav-like family member 1

Names: 50 kDa nuclear polyadenylated RNA-binding protein; CELF-1; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; EDEN-BP homolog; RNA-binding protein BRUNOL-2; brain protein F41; bruno-like protein 2; deadenylation factor CUG-BP; deadenylation factor EDEN-BP; embryo deadenylation element-binding protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244891.2 → NP_001231820.1 CUGBP Elav-like family member 1 isoform 2

See identical proteins and their annotated locations for NP_001231820.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate exon in the 5' region, which results in a downstream AUG start codon, and has an additional segment in the 3' UTR, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AL672241

Consensus CDS

CCDS16421.1

UniProtKB/Swiss-Prot

A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37

Related

ENSMUSP00000136109.2, ENSMUST00000177642.8

Conserved Domains (3) summary

cd12638
Location:394 → 485

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
NM_001244903.2 → NP_001231832.1 CUGBP Elav-like family member 1 isoform 2

See identical proteins and their annotated locations for NP_001231832.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in a downstream AUG start codon, and has an additional segment in the 3' UTR, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AL672241

Consensus CDS

CCDS16421.1

UniProtKB/Swiss-Prot

A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37

Related

ENSMUSP00000070438.8, ENSMUST00000068747.14

Conserved Domains (3) summary

cd12638
Location:394 → 485

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
NM_001406164.1 → NP_001393093.1 CUGBP Elav-like family member 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL672241

Related

ENSMUSP00000107082.3, ENSMUST00000111455.9
NM_001406165.1 → NP_001393094.1 CUGBP Elav-like family member 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406166.1 → NP_001393095.1 CUGBP Elav-like family member 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL672241

UniProtKB/Swiss-Prot

A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37
NM_001406167.1 → NP_001393096.1 CUGBP Elav-like family member 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL672241

UniProtKB/Swiss-Prot

A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37

Related

ENSMUSP00000107076.2, ENSMUST00000111449.8
NM_001406168.1 → NP_001393097.1 CUGBP Elav-like family member 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406169.1 → NP_001393098.1 CUGBP Elav-like family member 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406170.1 → NP_001393099.1 CUGBP Elav-like family member 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406171.1 → NP_001393100.1 CUGBP Elav-like family member 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406172.1 → NP_001393101.1 CUGBP Elav-like family member 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL672241

UniProtKB/TrEMBL

A0A0R4J0T5
NM_001406173.1 → NP_001393102.1 CUGBP Elav-like family member 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL672241

UniProtKB/TrEMBL

A0A0R4J0T5
NM_001406174.1 → NP_001393103.1 CUGBP Elav-like family member 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL672241

UniProtKB/TrEMBL

A0A0R4J0T5

Related

ENSMUSP00000064323.7, ENSMUST00000068726.13
NM_001406175.1 → NP_001393104.1 CUGBP Elav-like family member 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL672241

UniProtKB/TrEMBL

A0A0R4J0T5
NM_001406176.1 → NP_001393105.1 CUGBP Elav-like family member 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406177.1 → NP_001393106.1 CUGBP Elav-like family member 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406178.1 → NP_001393107.1 CUGBP Elav-like family member 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406179.1 → NP_001393108.1 CUGBP Elav-like family member 1 isoform 9

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406180.1 → NP_001393109.1 CUGBP Elav-like family member 1 isoform 10

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406181.1 → NP_001393110.1 CUGBP Elav-like family member 1 isoform 11

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406182.1 → NP_001393111.1 CUGBP Elav-like family member 1 isoform 11

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406183.1 → NP_001393112.1 CUGBP Elav-like family member 1 isoform 12

Status: VALIDATED

Source sequence(s)

AL672241
NM_001406184.1 → NP_001393113.1 CUGBP Elav-like family member 1 isoform 13

Status: VALIDATED

Source sequence(s)

AL672241
NM_017368.4 → NP_059064.2 CUGBP Elav-like family member 1 isoform 1

See identical proteins and their annotated locations for NP_059064.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AL672241

Consensus CDS

CCDS16420.1

UniProtKB/Swiss-Prot

P28659

Related

ENSMUSP00000005643.8, ENSMUST00000005643.14

Conserved Domains (3) summary

cd12638
Location:421 → 512

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
NM_198683.3 → NP_941955.1 CUGBP Elav-like family member 1 isoform 2

See identical proteins and their annotated locations for NP_941955.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AL672241

Consensus CDS

CCDS16421.1

UniProtKB/Swiss-Prot

A2AFW9, A2AFX0, A2AFX1, A2AFX2, P28659, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37

Related

ENSMUSP00000107078.4, ENSMUST00000111451.10

Conserved Domains (3) summary

cd12638
Location:394 → 485

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

90770604..90849842

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158049.1 → XP_036013942.1 CUGBP Elav-like family member 1 isoform X13

Conserved Domains (3) summary

cd12638
Location:334 → 423

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_030247110.1 → XP_030102970.1 CUGBP Elav-like family member 1 isoform X7

Related

ENSMUSP00000107075.2, ENSMUST00000111448.2

Conserved Domains (3) summary

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12638
Location:391 → 482

RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_030247123.1 → XP_030102983.1 CUGBP Elav-like family member 1 isoform X1

Conserved Domains (3) summary

cd12638
Location:422 → 513

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_030247114.1 → XP_030102974.1 CUGBP Elav-like family member 1 isoform X9

Conserved Domains (3) summary

cd12638
Location:362 → 451

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_036158039.1 → XP_036013932.1 CUGBP Elav-like family member 1 isoform X9

Conserved Domains (3) summary

cd12638
Location:362 → 451

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_030247118.1 → XP_030102978.1 CUGBP Elav-like family member 1 isoform X10

Conserved Domains (3) summary

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12638
Location:361 → 450

RRM3_CELF1_2; RNA recognition motif 3 in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_030247086.1 → XP_030102946.1 CUGBP Elav-like family member 1 isoform X3

Conserved Domains (3) summary

cd12638
Location:418 → 509

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_017315295.1 → XP_017170784.1 CUGBP Elav-like family member 1 isoform X1

Conserved Domains (3) summary

cd12638
Location:422 → 513

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_036158048.1 → XP_036013941.1 CUGBP Elav-like family member 1 isoform X12

Conserved Domains (3) summary

cd12638
Location:335 → 424

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_036158029.1 → XP_036013922.1 CUGBP Elav-like family member 1 isoform X5

UniProtKB/TrEMBL

A0A0R4J0T5

Conserved Domains (3) summary

cd12638
Location:395 → 486

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_198016.1: Suppressed sequence

Description

NM_198016.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.