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    Cpsf7 cleavage and polyadenylation specific factor 7 [ Mus musculus (house mouse) ]

    Gene ID: 269061, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cpsf7provided by MGI
    Official Full Name
    cleavage and polyadenylation specific factor 7provided by MGI
    Primary source
    MGI:MGI:1917826
    See related
    Ensembl:ENSMUSG00000034820 AllianceGenome:MGI:1917826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730453I16Rik; C330017N18Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA alternative polyadenylation; pre-mRNA cleavage required for polyadenylation; and protein-containing complex assembly. Predicted to act upstream of or within mRNA processing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including blood vessel; brain; olfactory epithelium; and retina. Orthologous to human CPSF7 (cleavage and polyadenylation specific factor 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 30.5), whole brain E14.5 (RPKM 27.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 6.6 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10502594..10525099)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10525223..10547735)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene stabilizer of axonemal microtubules 4 Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene transmembrane protein 138 Neighboring gene cytochrome b561 family, member A3 Neighboring gene triokinase, FMN cyclase Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos. Li N, et al. Stem Cell Reports, 2023 Jan 10. PMID 36563685, Free PMC Article
    2. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
    3. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
    4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46982

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA alternative polyadenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA alternative polyadenylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cleavage factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor subunit 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164272.2 → NP_001157744.1  cleavage and polyadenylation specificity factor subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001157744.1

      Status: VALIDATED

      Source sequence(s)
      AC125093
      UniProtKB/Swiss-Prot
      Q8BTV2
      Conserved Domains (1) summary
      cd12644
      Location:81 → 170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

    2. NM_001362450.2 → NP_001349379.1  cleavage and polyadenylation specificity factor subunit 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125093

    3. NM_172302.4 → NP_758506.3  cleavage and polyadenylation specificity factor subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_758506.3

      Status: VALIDATED

      Source sequence(s)
      AC125093
      Consensus CDS
      CCDS29579.1
      UniProtKB/Swiss-Prot
      Q3TNF1, Q8BKE7, Q8BTV2, Q8CFS8
      Related
      ENSMUSP00000038958.4, ENSMUST00000038379.5
      Conserved Domains (2) summary
      COG0724
      Location:20 → 231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12644
      Location:81 → 170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10502594..10525099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250956.2 → XP_030106816.1  cleavage and polyadenylation specificity factor subunit 7 isoform X4

      Conserved Domains (1) summary
      cl17169
      Location:23 → 101
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_006527117.4 → XP_006527180.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

      See identical proteins and their annotated locations for XP_006527180.1

      Conserved Domains (1) summary
      cl17169
      Location:23 → 101
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_036161607.1 → XP_036017500.1  cleavage and polyadenylation specificity factor subunit 7 isoform X4

      Conserved Domains (1) summary
      cl17169
      Location:23 → 101
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_036161606.1 → XP_036017499.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:23 → 101
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_030250955.1 → XP_030106815.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:23 → 101
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_006527116.5 → XP_006527179.1  cleavage and polyadenylation specificity factor subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006527179.1

      UniProtKB/Swiss-Prot
      Q3TNF1, Q8BKE7, Q8BTV2, Q8CFS8
      Conserved Domains (2) summary
      COG0724
      Location:20 → 231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12644
      Location:81 → 170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

    7. XM_030250954.1 → XP_030106814.1  cleavage and polyadenylation specificity factor subunit 7 isoform X2

      Conserved Domains (1) summary
      cd12644
      Location:81 → 170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

    8. XM_006527119.2 → XP_006527182.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

      See identical proteins and their annotated locations for XP_006527182.1

      Conserved Domains (1) summary
      cl17169
      Location:23 → 101
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. XM_030250958.1 → XP_030106818.1  cleavage and polyadenylation specificity factor subunit 7 isoform X5

    10. XM_036161608.1 → XP_036017501.1  cleavage and polyadenylation specificity factor subunit 7 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTV2.2 GenPept UniProtKB/Swiss-Prot:Q8BTV2

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