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    Keap1 kelch-like ECH-associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 50868, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Keap1provided by MGI
    Official Full Name
    kelch-like ECH-associated protein 1provided by MGI
    Primary source
    MGI:MGI:1858732
    See related
    Ensembl:ENSMUSG00000003308 AllianceGenome:MGI:1858732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    INRF2; mKIAA0132
    Summary
    Enables disordered domain specific binding activity and identical protein binding activity. Involved in cellular protein metabolic process; cellular response to oxidative stress; and regulation of autophagy. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 41.2), adrenal adult (RPKM 36.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Keap1 in Genome Data Viewer
    Location:
    9 A3; 9 7.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21141026..21150628, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21229730..21239332, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36118 Neighboring gene predicted gene, 35977 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:20966019-20966202 Neighboring gene predicted gene, 39301 Neighboring gene phosphodiesterase 4A, cAMP specific Neighboring gene STARR-positive B cell enhancer ABC_E1781 Neighboring gene STARR-seq mESC enhancer starr_23485 Neighboring gene predicted gene, 16754 Neighboring gene STARR-seq mESC enhancer starr_23486 Neighboring gene STARR-positive B cell enhancer ABC_E8278 Neighboring gene sphingosine-1-phosphate receptor 5 Neighboring gene STARR-positive B cell enhancer mm9_chr9:21069491-21069792 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exploring the target scope of KEAP1 E3 ligase-based PROTACs. Du G, et al. Cell Chem Biol, 2022 Oct 20. PMID 36070758, Free PMC Article
    2. The Keap1 signaling in the regulation of HSP90 pathway. Bonura A, et al. Cell Stress Chaperones, 2022 May. PMID 35362892, Free PMC Article
    3. Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice. Onoki T, et al. Redox Biol, 2021 Jul. PMID 33857757, Free PMC Article
    4. Liquid-phase ASEM imaging of cellular and structural details in cartilage and bone formed during endochondral ossification: Keap1-deficient osteomalacia. Sakai E, et al. Sci Rep, 2021 Mar 11. PMID 33707458, Free PMC Article
    5. Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice. Tamatam CM, et al. Sci Rep, 2020 Nov 4. PMID 33149211, Free PMC Article

    See all (287) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.
      Title: GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.
    2. KEAP1-Mutant Lung Cancers Weaken Anti-Tumor Immunity and Promote an M2-like Macrophage Phenotype.
      Title: KEAP1-Mutant Lung Cancers Weaken Anti-Tumor Immunity and Promote an M2-like Macrophage Phenotype.
    3. Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.
      Title: Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.
    4. Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
      Title: Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
    5. FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
      Title: FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
    6. Nrf2 activation improves experimental rheumatoid arthritis.
      Title: Nrf2 activation improves experimental rheumatoid arthritis.
    7. Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation.
      Title: Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation.
    8. Curculigoside mitigates dextran sulfate sodium-induced colitis by activation of KEAP1-NRF2 interaction to inhibit oxidative damage and autophagy of intestinal epithelium barrier.
      Title: Curculigoside mitigates dextran sulfate sodium‑induced colitis by activation of KEAP1‑NRF2 interaction to inhibit oxidative damage and autophagy of intestinal epithelium barrier.
    9. MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
      Title: MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
    10. BRG1 mediates protective ability of spermidine to ameliorate osteoarthritic cartilage by Nrf2/KEAP1 and STAT3 signaling pathway.
      Title: BRG1 mediates protective ability of spermidine to ameliorate osteoarthritic cartilage by Nrf2/KEAP1 and STAT3 signaling pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (151)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to carbohydrate stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inclusion body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like ECH-associated protein 1
    Names
    NRF2 cytosolic inhibitor
    cytosolic inhibitor of Nrf2
    ring canal protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110305.1 → NP_001103775.1  kelch-like ECH-associated protein 1

      See identical proteins and their annotated locations for NP_001103775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AC163637, AK150485, AK159858, BY586021
      Consensus CDS
      CCDS22897.1
      UniProtKB/Swiss-Prot
      Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
      Related
      ENSMUSP00000062467.5, ENSMUST00000049567.10
      Conserved Domains (5) summary
      smart00612
      Location:471 → 517
      Kelch; Kelch domain
      PHA03098
      Location:95 → 596
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460 → 503
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:67 → 176
      BTB; BTB/POZ domain
      pfam07707
      Location:184 → 286
      BACK; BTB And C-terminal Kelch

    2. NM_001110306.1 → NP_001103776.1  kelch-like ECH-associated protein 1

      See identical proteins and their annotated locations for NP_001103776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AC163637, AK004738, BY586021, CJ179527
      Consensus CDS
      CCDS22897.1
      UniProtKB/Swiss-Prot
      Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
      Related
      ENSMUSP00000141840.2, ENSMUST00000193982.2
      Conserved Domains (5) summary
      smart00612
      Location:471 → 517
      Kelch; Kelch domain
      PHA03098
      Location:95 → 596
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460 → 503
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:67 → 176
      BTB; BTB/POZ domain
      pfam07707
      Location:184 → 286
      BACK; BTB And C-terminal Kelch

    3. NM_001110307.1 → NP_001103777.1  kelch-like ECH-associated protein 1

      See identical proteins and their annotated locations for NP_001103777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AK004738, BY586021
      Consensus CDS
      CCDS22897.1
      UniProtKB/Swiss-Prot
      Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
      Related
      ENSMUSP00000141807.2, ENSMUST00000194542.6
      Conserved Domains (5) summary
      smart00612
      Location:471 → 517
      Kelch; Kelch domain
      PHA03098
      Location:95 → 596
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460 → 503
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:67 → 176
      BTB; BTB/POZ domain
      pfam07707
      Location:184 → 286
      BACK; BTB And C-terminal Kelch

    4. NM_016679.4 → NP_057888.1  kelch-like ECH-associated protein 1

      See identical proteins and their annotated locations for NP_057888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2, 3, and 4 all encode the same protein.
      Source sequence(s)
      AC163637, AK076234, BY586021
      Consensus CDS
      CCDS22897.1
      UniProtKB/Swiss-Prot
      Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
      Related
      ENSMUSP00000131029.2, ENSMUST00000164812.8
      Conserved Domains (5) summary
      smart00612
      Location:471 → 517
      Kelch; Kelch domain
      PHA03098
      Location:95 → 596
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:460 → 503
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:67 → 176
      BTB; BTB/POZ domain
      pfam07707
      Location:184 → 286
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21141026..21150628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2X8.1 GenPept UniProtKB/Swiss-Prot:Q9Z2X8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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