Senp2 SUMO/sentrin specific peptidase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Senp2provided by MGI
Official Full Name: SUMO/sentrin specific peptidase 2provided by MGI
Primary source: MGI:MGI:1923076
See related: Ensembl:ENSMUSG00000022855 AllianceGenome:MGI:1923076
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SuPr-1; Smt3ip2; mKIAA1331; 2310007L05Rik; 4930538C18Rik
Summary: Enables SUMO-specific isopeptidase activity. Involved in fat cell differentiation and protein desumoylation. Acts upstream of or within several processes, including embryonic placenta development; negative regulation of DNA damage response, signal transduction by p53 class mediator; and regulation of cell cycle process. Located in cytoplasmic vesicle and nuclear body. Colocalizes with PML body. Is expressed in several structures, including blastocyst; central nervous system; early embryo; extraembryonic component; and retina. Orthologous to human SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 18.7), placenta adult (RPKM 14.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B1; 16 12.98 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (21828182..21868019)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (22009432..22049269)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury.
Title: SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury.
SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis.
Title: SENP2 restrains the generation of pathogenic Th17 cells in mouse models of colitis.
Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes.
Title: Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes.
Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.
Title: Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice.
SENP2-PLCbeta4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
Title: SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKalpha.
Title: The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKα.
SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPbeta.
Title: SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPβ.
Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.
Title: Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.
Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
Title: Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
Title: The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3) 1 citation
Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-44d3 (e-PCR)
- UniSTS:257814

AI646780 (e-PCR)
- UniSTS:180880

AW554757 (e-PCR)
- UniSTS:186065

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SUMO-specific endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deSUMOylase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in dorsal/ventral axis specification	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spongiotrophoblast layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophoblast giant cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with PML body	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sentrin-specific protease 2

Names: SUMO-1 protease-1; SUMO-1/Smt3-specific isopeptidase 2; SUMO/sentrin specific protease 2; axam2; sentrin/SUMO-specific protease SENP2

NP_001344353.1

EC 3.4.22.68

NP_083733.1

EC 3.4.22.68

XP_006522751.1

EC 3.4.22.68

XP_006522752.1

EC 3.4.22.68

XP_030105183.1

EC 3.4.22.68

XP_030105184.1

EC 3.4.22.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357424.1 → NP_001344353.1 sentrin-specific protease 2 isoform 2

Status: VALIDATED

Source sequence(s)

CT009567, CT030725

Conserved Domains (1) summary

COG5160
Location:302 → 507

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
NM_029457.3 → NP_083733.1 sentrin-specific protease 2 isoform 1

See identical proteins and their annotated locations for NP_083733.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

AK031030, CJ169147, CT009567, CT030725

Consensus CDS

CCDS28065.1

UniProtKB/Swiss-Prot

Q544T8, Q811R3, Q91ZX6, Q9D4Z0

Related

ENSMUSP00000023561.8, ENSMUST00000023561.8

Conserved Domains (1) summary

cl23802
Location:337 → 583

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RNA

NR_027488.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of a coding exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF368904, AK031030, CJ169147, CT009567, CT030725

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

21828182..21868019

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522688.3 → XP_006522751.1 sentrin-specific protease 2 isoform X1

Conserved Domains (1) summary

COG5160
Location:388 → 593

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
XM_006522689.5 → XP_006522752.1 sentrin-specific protease 2 isoform X3

Conserved Domains (1) summary

COG5160
Location:341 → 546

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
XM_030249324.2 → XP_030105184.1 sentrin-specific protease 2 isoform X4

Conserved Domains (1) summary

COG5160
Location:307 → 512

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
XM_030249323.2 → XP_030105183.1 sentrin-specific protease 2 isoform X2

Conserved Domains (1) summary

COG5160
Location:379 → 584

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]