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    Nepro nucleolus and neural progenitor protein [ Mus musculus (house mouse) ]

    Gene ID: 212547, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Neproprovided by MGI
    Official Full Name
    nucleolus and neural progenitor proteinprovided by MGI
    Primary source
    MGI:MGI:2384836
    See related
    Ensembl:ENSMUSG00000036208 AllianceGenome:MGI:2384836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Acts upstream of or within negative regulation of neuron differentiation and positive regulation of Notch signaling pathway. Located in nucleolus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in anauxetic dysplasia 3. Orthologous to human NEPRO (nucleolus and neural progenitor protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.9), limb E14.5 (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B4; 16 29.04 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44544645..44559994)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44724301..44738856)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40908 Neighboring gene predicted gene, 46571 Neighboring gene VISTA enhancer mm1637 Neighboring gene predicted gene, 30311 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:44692039-44692222 Neighboring gene STARR-seq mESC enhancer starr_40911 Neighboring gene STARR-positive B cell enhancer ABC_E10905 Neighboring gene predicted gene, 30445 Neighboring gene STARR-positive B cell enhancer mm9_chr16:44746411-44746712 Neighboring gene GTP-binding protein 8 (putative) Neighboring gene STARR-positive B cell enhancer ABC_E5543 Neighboring gene CD200 receptor 1 Neighboring gene lactate dehydrogenase A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch. Muroyama Y, et al. Development, 2009 Dec. PMID 19906856
    2. Nepro is localized in the nucleolus and essential for preimplantation development in mice. Hashimoto M, et al. Dev Growth Differ, 2015 Sep. PMID 26178919
    3. BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. Tiberi L, et al. Nat Neurosci, 2012 Dec. PMID 23160044
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Nepro is a nucleolus-associated protein, and its loss leads to the apoptosis before blastocyst formation in mice.
      Title: Nepro is localized in the nucleolus and essential for preimplantation development in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Clone Names

    • MGC27931

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleolus and neural progenitor protein
    Names
    neural progenitor protein
    protein nepro

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416872.1 → NP_001403801.1  nucleolus and neural progenitor protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122217, AC124180

    2. NM_001416873.1 → NP_001403802.1  nucleolus and neural progenitor protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122217, AC124180

    3. NM_001416874.1 → NP_001403803.1  nucleolus and neural progenitor protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122217, AC124180

    4. NM_145972.5 → NP_666084.1  nucleolus and neural progenitor protein isoform 1

      See identical proteins and their annotated locations for NP_666084.1

      Status: VALIDATED

      Source sequence(s)
      AC122217, AC124180
      Consensus CDS
      CCDS28187.1
      UniProtKB/Swiss-Prot
      Q8R2U2
      UniProtKB/TrEMBL
      Q3TS42
      Related
      ENSMUSP00000038779.8, ENSMUST00000048788.14
      Conserved Domains (1) summary
      pfam14780
      Location:12 → 202
      DUF4477; Domain of unknown function (DUF4477)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      44544645..44559994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2U2.1 GenPept UniProtKB/Swiss-Prot:Q8R2U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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